嗜酸性粒细胞在慢性阻塞性肺疾病中的研究现状

Research Status of Eosinophils in Chronic Obstructive Pulmonary Disease

慢性阻塞性肺疾病(COPD)是一种复杂的异质性疾病,其气道炎症以中性粒细胞、巨噬细胞为主。近年研究发现某些COPD患者存在气道嗜酸性粒细胞(EOS)炎症,且具有某些明显特征,这提示了EOS参与了部分COPD患者的发病环节。鉴于EOS在COPD气道炎症中发病的重要性,本文就EOS与COPD的关系进行综述,以期为COPD的临床诊疗提供帮助。

Chronic obstructive pulmonary disease(COPD)is a complex heterogeneous disease,and its airway inflammation is dominated by neutrophils and macrophages.Recent studies have found that some COPD patients have airway eosinophil(EOS)inflammation and have some obvious characteristics,which suggests that EOS is involved in the pathogenesis of some COPD patients.In view of the importance of EOS in the pathogenesis of COPD airway inflammation,this article reviews the relationship between EOS and COPD,in order to provide help for the clinical diagnosis and treatment of COPD.