颈椎病与颈椎生理曲度异常相关性meta分析

Meta-analysis of the correlation between cervical spondylosis and abnormal physiological curvature of the cervical spine

目的 系统分析颈椎病与颈椎生理曲度异常的相关性。方法 计算机检索中国知网、Pub Med等数据库,搜索以颈椎病与颈椎曲度的关系为主题的病例对照研究文献,检索时限为2010年1月1日至2023年1月1日。采用纽卡斯尔-渥太华量表(NOS)评价文献质量,将得分≥6分的文献纳入研究,运用Rev Man5.4软件进行meta分析。结果 纳入11篇文献,共3525例研究对象,其中颈椎病组2275例、正常组1250例。异质性检验P=0.008,I2=59%,存在较大异质性,进行敏感性分析后剔除1篇文献,纳入10篇文献,共3350例研究对象,其中颈椎病组2161例、正常组1189例,经meta分析结果显示,OR=13.36,95%CI(10.72,16.66)。结论 颈椎病与颈椎生理曲度异常之间具有高度相关性;不同年龄的人颈椎生理曲度异常和颈椎病的相关性不同。

Objective To systematically analyze the correlation between cervical spondylosis and abnormal physiological curvature of the cervical spine.Methods A computer search was conducted on databases such as CNKI and PubMed to search for case-control research literature on the relationship between cervical spondylosis and cervical curvature.The search period was from January 1,2010 to January 1,2023.The Newcastle-Ottawa scale(NOS)was used to evaluate the quality of the literature.Literature with scores≥6 was included in the study,and meta-analysis was conducted using RevMan5.4 software.Results 11 articles and a total of 3525 study subjects were included,with 2275 cases in the cervical spondylosis group and 1250 cases in the normal group.P=0.008 for heterogeneity testing,I2=59%,with significant heterogeneity.After s ensitivity analysis,one article was excluded and 10 articles were included,with a total of 3350 study subjects,with 2161 cases in the cer vical spondylosis group and 1189 cases in the normal group.The results of the meta-analysis showed that OR=13.36,95%CI(10.72,16.66).Conclusion There is a high correlation between cervical spondylosis and abnormal physiological curvature of the cervical spine;The correlation between abnormal physiological curvature of the cervical spine and cervical spondylosis varies among people of different ages.