摘要
目的观察新生化颗粒联合卡前列素氨丁三醇注射液治疗高危妊娠产妇产后出血的临床疗效。方法将102例高危妊娠产后出血产妇按照入院顺序奇偶性分为2组,对照组51例采用卡前列素氨丁三醇注射液肌肉注射;治疗组51例在对照组治疗基础上加服新生化颗粒。2组均连续治疗1周。比较2组治疗前后出血量、休克指数(SI)、血压、凝血酶原时间(PT)、血浆凝血酶时间(TT)、纤维蛋白原(FIB)水平,并统计临床疗效及不良反应发生情况。结果治疗组总有效率94.12%(48/51),对照组总有效率92.16%(47/51),2组比较差异无统计学意义(P>0.05)。2组产后24 h内平均出血量比较差异无统计学意义(P>0.05),治疗组治疗后平均出血量低于对照组(P<0.05)。2组休克程度比较差异无统计学意义(P>0.05)。2组治疗后舒张压、收缩压均较本组治疗前升高(P<0.05),且治疗组治疗后均高于对照组(P<0.05)。2组治疗后PT、TT均较本组治疗前缩短(P<0.05),FIB均升高(P<0.05),且治疗组治疗后血浆PT、TT短于对照组(P<0.05),FIB水平高于对照组(P<0.05)。对照组治疗期间不良反应发生率为15.69%(8/51),高于治疗组的3.92%(2/51)(P<0.05)。结论采用新生化颗粒联合卡前列素氨丁三醇注射液治疗高危妊娠产妇产后出血,可有效改善凝血功能,降低产妇产后出血量,安全性较高,效果显著。
Objective To study the clinical effect of Xinshenghua Granules combined with carboprost tromethamine on postpartum hemorrhage(PPH)in high-risk pregnant women.Methods A total of 102 high-risk pregnant women were enrolled and assigned into the control group(n=51)and the treatment group(n=51)according to the order of admission,and the patients of the control group were injected with carboprost tromethamine.The patients of the treatment group were additionally oral administration of Xinshenghua Granules on the basis of the control group.A 1-week treatment was performed to compare PPH,shock index(SI),blood pressure,prothrombin time(PT),plasma thrombin time(TT),fibrinogen(FIB)level,adverse reactions and clinical treatment effects between groups before and after treatment.Results After delivery,there was no significant difference in total effective rate between the treatment group and the control group(94.12%[48/51]vs 92.16%[47/51],P>0.05).There was no significant difference in the average amount of 24 hours PPH between the two groups(P>0.05).After 1 week,the average amount of PPH in the treatment group was significantly lower than that in the control group(P<0.05).After delivery,there was no significant difference in the SI scores between groups(P>0.05),the levels of diastolic blood pressure(DBP)and systolic blood pressure(SBP)in the both groups were significantly higher after delivery than those before treatment(P<0.05),and which were more pronounced in the treatment group than in the control group(P<0.05).After delivery,significant shorter PT and TT and significant increased FIB were detected in the both groups(all P<0.05),and there were significant differences in PT,TT and FIB between the treatment group and the control group(all P<0.05).The incidence of adverse reactions in the control group was significantly higher than that in the treatment group(15.69%[8/51]vs 3.92%[2/51],P<0.05).Conclusion For high-risk pregnant women with PPH,Xinshenghua Granules combined with carboprost tromethamine can effectively improve blood clotting and reduce the PPH volume,with high safety and significant effect.
作者
李灏
余洁
桑琳
LI Hao;YU Jie;SANG Lin(Department of Obstetrics and Gynecology,the Second People's Hospital of Hefei,Hefei,Anhui 230012)
出处
《河北中医》
2023年第8期1302-1305,共4页
Hebei Journal of Traditional Chinese Medicine
关键词
高危妊娠
产后出血
中西医结合疗法
High-risk pregnancy
Postpartum hemorrhage
Integrated traditional Chinese and Western medicine therapy