中医情志干预联合饮食指导对癌因性疲乏患者的疗效及对营养状态的影响

Effect of traditional Chinese medicine emotional intervention combined with diet guidance on patients with cancer-related fatigue and its influence on nutrition index

目的观察中医情志干预联合饮食指导对癌因性疲乏(CRF)患者的疗效及对患者营养的影响。方法将200例CRF患者按照随机数字表法分为2组,对照组100例采用常规干预,观察组100例采用中医情志干预联合饮食指导方案。比较2组干预后临床疗效及干预前后2组Piper疲乏修订量表(PFS-R)评分、卡氏功能状态评分(KPS)、营养指标[前白蛋白(PA)、血清总蛋白(TP)、转铁蛋白(Tf)、白蛋白(ALB)及营养指数(PNI)]、阿森斯失眠量表(AIS)评分变化。结果观察组总有效率为97.00%(97/100),高于对照组的90.00%(90/100)(P<0.05)。与本组干预前比较,干预后2组PFS-R、AIS评分均降低(P<0.05),KPS评分均升高(P<0.05);干预后,观察组PFS-R、AIS评分低于对照组(P<0.05),KPS评分高于对照组(P<0.05)。干预后,2组PA、TP、Tf、ALB水平及PNI均较本组干预前升高(P<0.05),且观察组均高于对照组(P<0.05)。结论中医情志干预联合饮食指导对CRF患者疗效显著,可有效缓解患者疲劳程度,改善睡眠质量和生活质量,提高机体营养。

Objective To explore the effect of traditional Chinese medicine(TCM)emotional intervention combined with diet guidance on patients with cancer-related fatigue(CRF)and its influence on nutrition index.Methods A total of 200 CRF patients were randomized 1∶1 to receive routine intervention(the control group)or TCM emotional intervention combined with diet guidance(the observation group).The clinical efficacy,the revised piper fatigue scale(PFS-R)score,Karnofsky performance status(KPS)score,nutritional index(prealbumin[PA],serum total protein[TP],transferrin[Tf],albumin[ALB]and prognostic nutritional index[PNI])and Athens Insomnia Scale(AIS)score were included as comparisons between groups before and after treatment.Results After nursing,the effective rate in the observation group was significantly higher than in the control group(97.00%[97/100]vs 90.00%[90/100],P<0.05).Significant decreased PFS-R and AIS score,and increased KPS score were detected in the two groups(all P<0.05),which were significant differences between the observation group and the control group(all P<0.05).PA,TP,Tf,ALB,PNI in the both group were significantly higher(P<0.05),and which in the observation group were more pronounced(P<0.05).Conclusion The nursing effect of TCM emotional intervention combined with diet guidance on CRF patients is significant,which can effectively relieve fatigue,improve sleep quality and quality of life,and improve body nutrition.