基于患者报告的特应性皮炎患者生活质量测量工具的研究进展

Update of patient-reported quality-of-life measurement instruments for patients with atopic dermatitis

特应性皮炎(AD)是一种慢性炎症性皮肤病,在非致命性皮肤疾病中疾病负担位列第一。剧烈瘙痒和反复发作严重影响患者的心理和社会功能,导致患者生活质量明显下降。采用有效的测量工具对AD患者的生活质量进行评估,有利于提高患者的照护体验,改善AD临床结局。本文对基于患者报告的AD患者相关普适性生活质量量表、皮肤病生活质量特殊量表、AD生活质量专用量表进行综述,表明普适性生活质量评估量表可用于比较AD与非皮肤病患者的生活质量,皮肤病生活质量特殊量表可用于比较不同皮肤病患者的生活质量,皮肤病生活质量特殊量表与AD生活质量专用量表可能具有更大的鉴别能力,对于细微变化的特异性和敏感度较高。在临床实践和研究中如何选择合适的量表取决于研究的问题以及所使用量表的适用人群。

Atopic dermatitis(AD)is a chronic inflammatory skin disease with the highest disease burden among non-fatal dermatoses.Severe itching and frequent recurrence seriously affect the patients'psychological and social functions,resulting in a significant decline in the patients'quality of life.Using effective measurement instrument to assess the quality of life is an effective way to evaluate the quality of life of AD patients,and to improve patients'care experience and the clinical outcomes.Here,we review the patient-reported quality-of-life measurement instruments,including generic instruments,dermatology-specific instruments,and disease-specific instruments used in AD.The generic instruments can be used to compare the quality of life of patients with AD and non-skin diseases,while the dermatology-specific instruments can be used to compare the quality of life of patients with different skin diseases.Dermatology-specific instruments and disease-specific instruments used in AD may have greater discriminatory power and higher specificity and sensitivity for subtle changes.How to choose the appropriate scale in clinical practice and research depends on the research question and the applicable population.