丙卡特罗联合异丙托溴铵缓解哮喘患者小气道功能障碍的效果

The effect of combination of procaterol and ipratropium bromide on alleviating small airway dysfunction in asthma patients

目的观察丙卡特罗联合异丙托溴铵在缓解哮喘患者小气道功能障碍的效果。方法选取2021年4月—2022年9月解放军总医院海南医院呼吸内科诊治哮喘患者98例作为研究对象,按照随机数字表法以1∶1比例分为观察组、对照组,各49例。对照组采用丙卡特罗治疗,观察组采用丙卡特罗联合异丙托溴铵治疗。治疗2周后比较2组疗效,治疗前后临床表现评分、肺功能[第1秒呼气量(FEV_(1))、用力肺活量(FVC)、最大呼气峰值流速(PEF)]、小气道功能[用力呼吸50%肺活量(FEF50)、用力呼吸75%肺活量(FEF75)、最大呼气中期流量(MMEF75/25)]以及不良反应发生率。结果治疗2周后,观察组总有效率显著高于对照组(93.88%vs.79.59%,χ^(2)/P=4.346/0.037);治疗2周后观察组各临床表现评分(胸闷、咳嗽、喘息、哮鸣音)均显著低于对照组(t/P=6.141/<0.001、3.940/<0.001、5.824/<0.001、3.957/<0.001),FEV_(1)、FVC、PEF、FEF50、FEF75、MMEF75/25水平均高于对照组(t/P=2.703/0.008、2.001/0.048、4.810/<0.001、3.382/0.001、5.260/<0.001、3.328/0.001);2组不良反应发生率比较,差异无统计学意义(χ^(2)/P=0.178/0.674)。结论丙卡特罗联合异丙托溴铵治疗哮喘效果显著,可有效改善哮喘症状,对缓解小气道功能障碍、提高肺功能均有良好效果,安全性高。

Objective To observe the effect of combination of procaterol and ipratropium bromide on alleviating small airway dysfunction in asthma patients.Methods Ninety-eight asthma patients diagnosed and treated in the Respiratory Department of Hainan Hospital of the People's Liberation Army General Hospital from April 2021 to September 2022 were selected as the research subjects.They were randomly divided into an observation group and a control group in a 1:1 ratio using a random number table method,with 49 patients in each group.The control group was treated with procaterol,while the observation group was treated with procaterol combined with ipratropium bromide.After 2 weeks of treatment,the efficacy of the two groups was compared,including symptom scores,pulmonary function(FEV_(1),FVC,PEF),small airway function(50%FEF50,75%FEF75,MMEF75/25),and incidence of adverse reactions before and after treatment.Results After 2 weeks of treatment,the total effective rate of the observation group was significantly higher than that of the control group(93.88%vs.79.59%,χ^(2)/P=4.346/0.037).After treatment,the symptom scores(chest tightness,cough,wheezing,wheezing)of the observation group were lower than those of the control group(t/P=6.141/<0.001,3.940/<0.001,5.824/<0.001,3.957/<0.001),and the levels of FEV_(1),FVC,PEF,FEF50,FEF75,and MMEF75/25 were higher than thoseof the control group(t/P=2.703/0.008,2.001/0.048,4.810/<0.001,3.382/0.001,5.260/0.048,3.328/0.001).There was no statistically significant difference in the incidence of adverse reactions between the two groups(χ^(2)/P=0.178/0.674).Conclusion The combination of procaterol and ipratropium bromide has a significant therapeutic effect on asthma,effectively improving asthma symptoms,alleviating small airway dysfunction,and improving lung function,with high safety.