清金化痰汤联合西医常规治疗用于痰热蕴肺型肺炎的疗效及对免疫功能的影响

The therapeutic effect of Qingjin Huatan decoction combined with conventional western medicine treatment on phlegm-heat accumulation lung type pneumonia and its impact on immune function

目的探讨清金化痰汤联合西医常规治疗用于痰热蕴肺型肺炎患者的疗效及对其免疫功能的影响,为临床提供参考。方法回顾性分析2019年9月至2022年9月黄山市中医医院收治的60例痰热蕴肺型肺炎患者的临床资料。根据治疗方法不同分为观察组(采用清金化痰汤联合西医常规治疗,30例)和对照组(采用单纯西医常规治疗,30例)。比较两组患者治疗效果、炎症因子水平[C反应蛋白(CRP)、降钙素原(PCT)及白细胞介素-6(IL-6)]、免疫功能指标[CD4+T淋巴细胞百分比、CD8+T淋巴细胞百分比及CD4+/CD8+比值]及不良反应发生情况。结果观察组患者整体疗效优于对照组(P<0.05);但两组患者总有效率比较,差异无统计学意义(P>0.05)。治疗后,两组患者血清CRP、PCT及IL-6水平低于治疗前,且观察组低于对照组(P<0.05)。治疗后,两组患者CD4+T淋巴细胞百分比和CD4+/CD8+比值高于治疗前,CD8+T淋巴细胞百分比低于治疗前,且观察组CD4+T淋巴细胞百分比和CD4+/CD8+比值高于对照组,CD8+T淋巴细胞百分比低于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论清金化痰汤联合西医治疗痰热蕴肺型肺炎疗效理想,有助于抑制炎症反应,改善免疫功能。

Objective Exploring the therapeutic effect of Qingjin Huatan decoction combined with conventional western medicine treatment on phlegm-heat accumulation lung type pneumonia and its impact on its immune function,providing reference for clinical practice.Methods Retrospective analysis was made on the clinical data of 60 cases of phlegm-heat accumulation lung type pneumonia admitted to Huangshan City Hospital of Traditional Chinese Medicine from September 2019 to September 2022.According to different treatment methods,they were divided into the observation group(30 cases were treated with Qingjin Huatan decoction combined with conventional western medicine)and the control group(30 cases were treated with simple conventional western medicine).The treatment effect,inflammatory factor levels[C reactive protein(CRP),procalcitonin(PCT)and interleukin-6(IL-6)],immune function indicators(CD4+T lymphocyte percentage,CD8+T lymphocyte percentage and CD4+/CD8+ratio)and occurrence of adverse reactions were compared between the two groups.Results The overall efficacy of the observation group was better than that of the control group(P<0.05).There was no significant difference in the total effective rate between the two groups(P>0.05).After treatment,the serum CRP,PCT,and IL-6 levels were lower in both groups than before treatment,and the observation group was lower than the control group(P<0.05).After treatment,the percentage of CD4+T lymphocytes and CD4+/CD8+ratio in two groups were higher than that before treatment,the percentage of CD8+T lymphocytes was lower than that before treatment,and the percentage of CD4+T lymphocytes and CD4+/CD8+ratio of patients in the observation group were higher than control group,and the percentage of CD8+T lymphocytes was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Qingjin Huatan decoction and western medicine has significant therapeutic effect on phlegm-heat accumulation lung type pneumonia,which helps to suppress inflammatory reactions,improve immune function.