血清免疫球蛋白检验对肝衰竭的诊断价值研究

Study on the value of serum immunoglobulin test in the diagnosis of liver failure

目的 探究血清免疫球蛋白检验对肝衰竭的诊断价值。方法 选取30例肝衰竭患者作为研究组,根据肝衰竭时期不同分为轻度组和中重度组,每组15例;另选择30例体检健康者作为对照组。两组均进行血清免疫球蛋白检验。比较研究组与对照组免疫球蛋白G(IgG)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)水平及总胆红素、白蛋白及凝血酶原活动度;比较研究组不同肝衰竭时期的IgG、IgA、IgM水平及总胆红素、白蛋白及凝血酶原活动度。结果 研究组IgG(23.52±5.61)g/L、IgA(13.21±3.61)g/L、IgM(12.62±4.10)g/L、总胆红素(382.43±32.64)μmol/L高于对照组的(11.20±4.31)g/L、(4.02±1.23)g/L、(3.76±1.21)g/L、(13.61±7.64)μmol/L,白蛋白(28.61±8.49)g/L、凝血酶原活动度(34.61±8.59)%低于对照组的(37.12±9.31)g/L、(91.35±9.67)%,差异均具有统计学意义(P<0.05)。中重度组IgG(26.37±9.12)g/L、IgA(17.58±6.43)g/L、IgM(17.51±6.35)g/L、总胆红素(420.61±31.26)μmol/L高于轻度组的(20.67±4.13)g/L、(8.84±1.52)g/L、(7.73±1.32)g/L、(344.25±17.63)μmol/L,白蛋白(22.70±8.36)g/L、凝血酶原活动度(31.23±8.56)%低于轻度组的(34.52±9.79)g/L、(37.99±6.25)%,差异均具有统计学意义(P<0.05)。结论 血清免疫球蛋白检验对肝衰竭具有显著的临床诊断价值,不仅能够提高诊断准确率,而且能够评估患者病情严重程度,值得临床推广使用。

Objective To investigate the value of serum immunoglobulin test in the diagnosis of liver failure.Methods 30 patients with liver failure were selected as the study group and divided into mild group and moderately severe group according to different stages of liver failure,with 15 cases in each group.30 healthy subjects were selected as the control group.Serum immunoglobulin test was performed in both groups.Comparison was made on levels of immunoglobulin G(IgG),immunoglobulin A(IgA),immunoglobulin M(IgM)and total bilirubin,albumin and prothrombin activity between the study group and control group,as well as the levels of IgG,IgA and IgM and the total bilirubin,albumin and prothrombin activity of patients at different stages of liver failure in the study group.Results The study group had IgG of(23.52±5.61)g/L,IgA of(13.21±3.61)g/L,IgM of(12.62±4.10)g/L,and total bilirubin of(382.43±32.64)μmol/L,which were higher than those of(11.20±4.31)g/L,(4.02±1.23)g/L,(3.76±1.21)μmol/L,and(13.61±7.64)μmol/L in the control group;the albumin of(28.61±8.49)g/L and prothrombin activity of(34.61±8.59)%in the study group was lower than those of(37.12±9.31)g/L and(91.35±9.67)%in the control group;the differences were statistically significant(P<0.05).The moderately severe group had IgG of(26.37±9.12)g/L,IgA of(17.58±6.43)g/L,IgM of(17.51±6.35)g/L,and total bilirubin of(420.61±31.26)μmol/L,which were higher than those of(20.67±4.13)g/L,(8.84±1.52)g/L,(7.73±1.32)g/L,and(344.25±17.63)μmol/L in the mild group;the albumin of(22.70±8.36)g/L and prothrombin activity of(31.23±8.56)%in the moderately severe group were lower than those of(34.52±9.79)g/L and(37.99±6.25)%in the mild group;the differences were statistically significant(P<0.05).Conclusion Serum immunoglobulin test has significant clinical value for the diagnosis of liver failure,which can not only improve the diagnostic accuracy,but also can assess the severity of the patient's condition,which is worthy of clinical promotion.