腹腔镜下修补术治疗胃十二指肠溃疡穿孔的效果分析

Analysis on effect of Laparoscopic Repair in Treatment of Gastroduodenal Ulcer Perforation

目的:探讨腹腔镜下修补术治疗胃十二指肠溃疡穿孔的效果。方法:选取2020年1月—2022年3月山东省单县东大医院收治的胃十二指肠溃疡穿孔患者78例作为研究对象,以随机数字表法分为对照组和观察组,各39例。对照组采用开腹手术治疗,观察组采用腹腔镜下修补术治疗。比较两组治疗效果、应激反应指标、胃肠功能。结果:观察组治疗总有效率高于对照组,差异有统计学意义(P=0.013 1)。术前,两组肿瘤坏死因子-α、白细胞介素-6、C反应蛋白水平比较,差异无统计学意义(P>0.05);术后24 h,观察组肿瘤坏死因子-α、白细胞介素-6、C反应蛋白水平低于对照组,差异有统计学意义(P<0.001)。术前,两组胃动素、胃泌素水平比较,差异无统计学意义(P>0.05);术后24 h,观察组胃动素、胃泌素水平高于对照组,差异有统计学意义(P<0.001)。结论:胃十二指肠溃疡穿孔患者采用腹腔镜下修补术治疗的效果显著,可减轻应激反应,促进胃肠功能恢复。

Objective:To explore the effect of laparoscopic repair in treatment of gastroduodenal ulcer perforation.Methods:A total of 78 patients with gastroduodenal ulcer perforation admitted to Shanxian Dongda Hospital of Shandong Province from January 2020 to March 2022 were selected as the study subjects.They were divided into a control group and an observation group using a random number table method,with 39 patients in each group.The control group received open surgery treatment,while the observation group received laparoscopic repair treatment.The treatment effect,stress response indexes,and gastrointestinal function were compared between the two groups.Results:The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.0131).Before surgery,there was no statistically significant difference in the levels of tumor necrosis factor-α,interleukin-6 and C-reactive protein between the two groups(P>0.05).At 24 h after surgery,the levels of tumor necrosis factor-α,interleukin-6 and C-reactive protein in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.001).Before surgery,there was no statistically significant difference in the levels of motilin and gastrin between the two groups(P>0.05).At 24 h after surgery,the levels of motilin and gastrin in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.001).Conclusion:Laparoscopic repair surgery is significantly effective in the treatment of patients with gastroduodenal ulcer perforation,which reduce stress response,and promote gastrointestinal function recovery.