艾司西酞普兰联合阿戈美拉汀治疗难治性抑郁症的效果

Effect of Escitalopram Combined With Agomelatine in Treatment of Treatment-Resistant Depression

目的:探讨艾司西酞普兰联合阿戈美拉汀治疗难治性抑郁症(TRD)的临床效果。方法:选取2019年5月—2022年5月常熟市第三人民医院收治的TRD患者60例作为研究对象,以随机数字表法分为对照组和干预组,各30例。对照组采用艾司西酞普兰治疗,干预组采用艾司西酞普兰联合阿戈美拉汀治疗。比较两组临床疗效、心理状态、生活质量评分、不良反应发生情况。结果:干预组治疗总有效率高于对照组,差异有统计学意义(P=0.015)。治疗后,两组抑郁、焦虑评分低于治疗前,且干预组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组生活质量各维度评分高于治疗前,且干预组高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:艾司西酞普兰联合阿戈美拉汀治疗TRD的效果显著,能够改善患者负性情绪,提升生活质量,并且不会增加不良反应。

Objective:To explore the clinical effect of escitalopram combined with agomelatine in the treatment of treatment-resistant depression(TRD).Methods:Sixty patients with TRD treated in Changshu Third People's Hospital from May 2019 to May2022 were selected as the study subjects.They were divided into control group and intervention group according to randomnumber table method,with 30 cases in each group.The control group was treated with escitalopram and the intervention group wastreated with escitalopram combined with agomelatine.The clinical efficacy,psychological state,quality of life score and adversereactions in the two groups were compared.Results:The total effective rate of treatment in the intervention group was higher thanthat in the control group,and the difference was statistically significant(P=0.015).After treatment,the depression and anxietyscores in the two groups were lower than those before treatment,and the intervention group was lower than the control group,andthe difference was statistically significant(P<0.05).After treatment,the quality of life scores in the two groups were higher thanthose before treatment,and the intervention group was higher than the control group,and the difference was statisticallysignificant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The effect of escitalopram combined with agomelatine in the treatment of TRD is significant.It can improve thenegative emotion of patients,improve the quality of life,and will not increase adverse reactions.