无创呼吸机治疗慢性阻塞性肺疾病急性加重期Ⅱ型呼吸衰竭患者的临床效果

Clinical Effect of Noninvasive Ventilator Treatment in Patients with Ⅱ-Type Respiratory Failure During Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:探讨无创呼吸机治疗慢性阻塞性肺疾病急性加重期Ⅱ型呼吸衰竭患者的临床效果。方法:选取2020年2月—2022年2月江苏省宜兴市官林医院收治的慢性阻塞性肺疾病急性加重期Ⅱ型呼吸衰竭患者100例作为研究对象,以随机数字表法分为对照组与观察组,各50例。对照组实施常规治疗,观察组在对照组基础上采用无创呼吸机治疗。比较两组肺功能指标、血气分析指标、治疗效果、不良反应发生情况。结果:治疗前,两组呼气峰流速(PEF)、第1秒用力呼气容积(FEV,)、用力肺活量(FVC)、FEV_(1)/FVC比较,差异无统计学意义(P>0.05);治疗后,两组PEF、FEV_(1)、FVC、FEV_(1)/FVC高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05)。治疗前,两组pH值、血氧饱和度、动脉血氧分压、动脉血二氧化碳分压比较,差异无统计学意义(P>0.05);治疗后,两组pH值、血氧饱和度、动脉血氧分压高于治疗前,且观察组高于对照组,两组动脉血二氧化碳分压均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率高于对照组,差异有统计学意义(P=0.027)。观察组不良反应发生率低于对照组,差异有统计学意义(P=0.046)。结论:慢性阻塞性肺疾病急性加重期Ⅱ型呼吸衰竭患者采用无创呼吸机治疗的效果显著,能够改善患者肺功能、血气分析指标,降低不良反应发生率。

Objective:To investigate the clinical effect of noninvasive ventilator in the treatment of patients with Ⅱ-type respiratory failure during acute exacerbation of chronic obstructive pulmonary disease.Methods:From February 2020 to February2022,100 patients with Ⅱ-type respiratory failure during acute exacerbation of chronic obstructive pulmonary disease admitted to Guanlin Hospital of Yixing City in Jiangsu Province were selected as the study subjects.They were divided into control group and observation group by random number table method,with 50 cases in each group.The control group implemented conventional treatment,and the observation group implemented noninvasive ventilator treatment on the basis of the control group.The lung function indexes,blood gas analysis indexes,treatment effect and occurrence of adverse reactions in two groups were compared.Results:Before treatment,there were no significant differences in peak expiratory flow rate(PEF),forced expiratory volume in the first second(FEV_1),forced vital capacity(FVC),and FEV_1/FVC between the two groups(P>0.05).After treatment,PEF,FEV_1,FVC,FEV_1/FVC in two groups were higher than those before treatment,and the observation group was higher than the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in pH,oxygen saturation,arterial partial pressure of oxygen and arterial partial pressure of carbon dioxide between the two groups(P>0.05).After treatment,the pH,oxygen saturation and arterial partial pressure of oxygen in the two groups were higher than those before treatment,and the observation group was higher than the control group;the arterial partial pressure of carbon dioxide in two groups was lower than that before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).The overall response rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P=0.027).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P=0.046).Conclusion:The treatment effect of noninvasive ventilator in patients with Ⅱ-type respiratory failure during acute exacerbation of chronic obstructive pulmonary disease is remarkable,which can improve the lung function and blood gas analysis indexes of patients and reduce the incidence of adverse reactions.