伊伐布雷定治疗稳定型心绞痛的效果分析

Effect Analysis of Ivabradine in Treatment of Stable Angina Pectoris

目的:探讨伊伐布雷定治疗稳定型心绞痛的临床效果。方法:选取2020年1月—2022年1月崇信县人民医院收治的稳定型心绞痛患者100例作为研究对象,以随机数字表法分为对照组与研究组,各50例。在常规治疗基础上,对照组采用阿替洛尔治疗,研究组采用伊伐布雷定治疗。比较两组治疗效果。结果:治疗后,两组心绞痛发作频率低于治疗前,且研究组低于对照组,两组发作持续时间短于治疗前,且研究组短于对照组,差异有统计学意义(P<0.05)。治疗后,两组静息状态下、最大运动量下的心率低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组一氧化氮、超氧化物歧化酶水平高于治疗前,且研究组高于对照组,两组内皮素-1、丙二醛水平低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P=0.037)。结论:伊伐布雷定治疗稳定型心绞痛的效果显著,能够降低心绞痛发作频率,缩短心绞痛持续时间,降低静息状态下和最大运动量下的心率,且对内皮功能具有保护作用。

Objective:To investigate the clinical effect of ivabradine in treatment of stable angina pectoris.Methods:A total of 100patients with stable angina pectoris in Chongxin County People's Hospital from January 2020 to January 2022 were selected as the study subjects.They were divided into control group and study group according to random number table method,with 50 cases in each group.On the basis of the conventional therapy,the control group was treated with atenolol,and the study group was treated with ivabradine.The treatment effect was compared between two groups.Results:After treatment,the frequency of angina attacks in the two groups was lower than that before treatment,and the study group was lower than the control group;the duration of the attacks in the two groups was shorter than that before treatment,and the study group was shorter than the control group,and the difference was statistically significant(P<0.05).After treatment,the heart rate at rest and at maximum exercise in the two groups was lower than that before treatment,and the study group was lower than the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of nitric oxide and superoxide dismutase in the two groups were higher than those before treatment,and the study group was higher than the control group;the levels of endothelin-1 and malondialdehyde in the two groups were lower than those before treatment,and the study group was lower than the control group,and the difference was statistically significant(P<0.05).The overall effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P=0.037).Conclusion:Ivabradine is effective in the treatment of stable angina pectoris,reduces the frequency of angina attacks,shortens the duration of angina,reduces the heart rate at rest and at maximum exercise,and has a protective effect on endothelial function.