摘要
近年来过敏性气道疾病的患病率逐年增加,IL-18与IL-18Rα结合后可启动下游的促炎信号而在过敏性气道疾病中起重要作用。IL-18也可与IL-18BP结合进而抑制其与IL-18Rα结合。因此,了解IL-18在过敏性气道疾病中的作用及其机制对于过敏性气道疾病的治疗、IL-18相关生物制剂的研发具有重要意义。
The prevalence of allergic airway diseases has been increasing in recent years.Interleukin-18(IL-18)plays an imperative role in allergic airway diseases by binding to IL-18Rα,thereby initiating the downstream proinflammatory pathway.IL-18 also binds to IL-18BP,thus inhibiting its binding to IL-18Rα.Therefore,further understanding of the role of IL-18 and its action mechanisms in allergic airway diseases is important for the treatment of allergic airway diseases,and for the development of IL-18-related biological agents.
作者
王君灵
何韶衡
WANG Junling;HE Shaoheng(Department of Critical Care Medicine,Henan Provincial People’s Hospital,Zhengzhou University People’s Hospital,Zhengzhou 450003;Allergy and Clinical Immunology Research Centre,The First Affiliated Hospital of Jinzhou Medical University,Jinzhou 121001,China)
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2023年第4期654-658,F0003,共6页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
国家自然科学基金面上项目(No.81471592)
辽宁省自然科学基金(No.2019-ZD-0801,No.LJKZ0796)
锦州医科大学博泽青年科技人才托举基金(No.JYBZQT2110)
博士后科研启动基金(No.ZC20230003)。
关键词
IL-18
过敏性鼻炎
过敏性哮喘
interleukin-18(IL-18)
allergic rhinitis
allergic asthma
