摘要
Epigenetic mechanisms,including DNA methylation,histone modification,and non-coding RNAs(ncRNAs),have been widely implicated in synaptic plasticity,memory formation,and memory consolidation.Dysregulation in epigenetic mechanisms has been reported in aged brains as well as age-related diseases,such as Alzheimer’s disease(AD).The reversible nature of epigenetic changes and their role in regulating gene expression in response to environmental stimuli make them exciting targets for therapy.Here,we will briefly discuss epigenetic changes in aged and AD brains,epigenetic biomarkers for diagnosis and prognosis,as well as HDAC-based treatment regimes.
作者
张娟
刘强
Juan Zhang;Qiang Liu(Department of Neurology,The First Affiliated Hospital of USTC,Center for Advanced Interdisciplinary Science and Biomedicine of IHM,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230027,China;Hefei National Laboratory for Physical Sciences at the Microscale,University of Science and Technology of China,Heifei 230027,China;Institute on Aging and Brain Disorders,The First Affiliated Hospital of USTC,University of Science and Technology of China,Hefei 230027,China;Anhui Province Key Laboratory of Biomedical Aging Research,University of Science and Technology of China,Hefei 230027,China;CAS Key Laboratory of Brain Function and Disease,University of Science and Technology of China,Hefei 230026,China)
基金
supported by the National Natural Science Foundation of China(82125009,31871082,91849101,32121002,82071185,32100794,and 92149303)
the National Key R&D Program of China(2020YFA0509300 and 2021YFA0804900)
the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB39000000)
CAS Project for Young Scientists in Basic Research(YSBR-013)
the Collaborative Innovation Program of Hefei Science Center,CAS(2022HSC-CIP003)
the Research Funds of Center for Advanced Interdisciplinary Science and Biomedicine of IHM(QYZD20220003)。
