基于电化学钴催化C-H活化的多样化手性骨架的构建

Electrochemical cobalt catalysis enabled construction of diverse chiral skeletons via C-H activation

Transition metal-catalyzed C-H functionalizations,which transform ubiquitous C-H bonds into diverse and valuable functionalities in a single step,have emerged as a direct and efficient methodology for constructing synthetically useful and multifunctional organic molecules[1].Despite the significant advantages,some drawbacks such as the requirement of a stoichiometric amount of chemical oxidant and the resulting low functional group tolerance,byproduct generation and separation issues remain to be solved(Fig.1a).Notably,the development of electrochemistry has introduced new dimensions to the field of organic synthesis[2].Employing electric energy as both an oxidant and a reductant in a single process,electrochemistry offers numerous advantages,including mild reaction conditions,a wide substrate scope,and enhanced sustainability.