抗阻力量训练对中老年轻度认知功能障碍患者的干预效果

Effect of resistance training intervention on middle-aged and elderly patients with mild cognitive impairment

目的探讨抗阻力量训练对中老年轻度认知功能障碍患者的干预效果。方法选取辽宁省大连市社区卫生服务中心中年和老年男性轻度认知功能障碍(MCI)患者各40例,年龄分别为(55±3)岁和(66±4)岁,并随机分成中年对照组(MC)和中年干预(MI)组、老年对照(OC)组和老年干预(OI)组。MC组和OC组进行常规的健康教育,MI组和OI组进行为期24周的抗阻力量训练,测试受试者认知功能、身体形态、激素水平、肌肉力量等指标变化。采用SPSS 19.0软件进行数据分析。根据数据类型,组间比较分别采用t检验及χ2检验。结果通过24周的运动干预,MI组蒙特利尔量表(MoCA)得分在T_(2)期显著高于MC组(P<0.05),OI组MoCA得分在T 2期显著性高于OC组(P<0.05)。与MC组相比,MI组身高、体质量和胸围略有增加,腰围和臀围略有下降,但差异无统计学意义;与OC组相比,OI组呈现相同的变化趋势。与MC组相比,MI组血清T和GH含量呈现升高的趋势,血清C含量呈现下降的趋势,血清T和C含量在T_(2)期差异有统计学意义(P<0.05);与OC组相比,OI组呈现相同的变化趋势,但改善效果优于MI组。MI组肌肉力量(握力)在T_(2)期显著高于MC组(P<0.05),OI组肌肉力量(握力)在T_(2)期显著高于OI组(P<0.05),改善效果优于MI组。结论24周的抗阻力量训练可以有效改善中老年MCI患者的认知功能,其干预效果受多方面因素的影响;对激素水平有积极的改善,OI组改善效果更好,但对体质量、身高和身体围度等改善效果不明显;能有效提高以握力为代表的肌肉力量,且OI组提高幅度更大。

Objective To investigate the effect of resistance training intervention on the middle-aged and elderly patients with mild cognitive impairment(MCI).Methods A total of 40 middle-aged[(55±3)years old]and 40 elderly[(66±4)years old]male MCI patients from Dalian Community Health Service Center were selected and randomly divided into middle-aged control(MC)group and middle-aged intervention(MI)group,old control(OC)group and old intervention(OI)group.MC and OC group received routine health education,MI and OI group received resistance training for 24 weeks.Changes were measured in cognitive function,body shape,hormone levels and muscle strength of subjects.SPSS statistics 19.0 was used for statistical analysis.Data comparison between two groups was perfomed using t test or χ^(2) test depending on data type.Results After 24-week of exercise intervention,compared with MC group,Montreal Cognitive Assessment(MoCA)score in MI group was significantly increased at T_(2) stage(P<0.05),MoCA score in OI group was significantly higher than that in OC group at T_(2) stage(P<0.05);compared with MC group,the body height,body mass and chest circumference of MI group increased slightly,and the waist circumference and hip circumference decreased slightly,but the difference was not statistically significant,and OI group showed the same trend compared with OC group;compared with MC group,the serum T and GH contents in MI group showed an increasing trend,while the serum C content showed a decreasing trend,and the serum T and C contents were significantly different at T 2 stage(P<0.05).Compared with OC group,OI group showed the same changing trend,and the improvement effect was better than that in MI group.Compared with MC group,muscle strength(grip strength)in MI group was significantly increased at T_(2) stage(P<0.05),muscle strength(grip strength)in OI group was significantly higher than that in OC group at T_(2) stage(P<0.05),and the improvement effect was better than that in MI group.Conclusion A 24-week resistance training can effectively improve the cognitive function of the middle-aged and elderly MCI patients,and the intervention effects are affected by multiply factors.It exerts a positive effect on hormone levels with a better effect in the OI group.However,the improvement effects on weight,height and body circumferences are not significant.It can effectively increase the muscle strength as represented by grip strength,and the increase is greater in OI group.