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CREMa overexpression decreases IL-2 production,induces a TH17 phenotype and accelerates autoimmunity 被引量:2

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摘要 Dear Editor,External cytokines produced by cells of the innate immune system induce the dif-ferentiation of CD4+T cells into helper T cell subsets with distinct functions and cytokine profiles.Apart from TH1 and TH2 cells a third subset of helper T cells has been described,which is characterized by increased expression of IL-17A,IL-17F,IL-21 and IL-22(TH17 cells).
出处 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2012年第2期121-123,共3页 分子细胞生物学报(英文版)
关键词 TH17 INDUCE cytokines
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同被引文献16

  • 1Koga, Tomohiro,Hedrich, Christian M,Mizui, Masayuki,Yoshida, Nobuya,Otomo, Kotaro,Lieberman, Linda A,Rauen, Thomas,Crispín, José C,Tsokos, George C.CaMK4-dependent activation of AKT/mTOR and CREM-[alpha] underlies autoimmunity-associated Th17 imbalance[J]. Journal of Clinical Investigation . 2014 (5)
  • 2Mélissa Noack,Pierre Miossec.Th17 and regulatory T cell balance in autoimmune and inflammatory diseases[J]. Autoimmunity Reviews . 2013
  • 3Christian M. Hedrich,Thomas Rauen,Jose C. Crispin,Tomohiro Koga,Christina Ioannidis,Melissa Zajdel,Vasileios C. Kyttaris,George C. Tsokos.cAMP-responsive Element Modulator α (CREMα) trans-Represses the Transmembrane Glycoprotein CD8 and Contributes to the Generation of CD3+CD4?CD8? T Cells in Health and Disease[J]. Journal of Biological Chemistry . 2013 (44)
  • 4Thomas Rauen,Christian M. Hedrich,Klaus Tenbrock,George C. Tsokos.cAMP responsive element modulator: a critical regulator of cytokine production[J]. Trends in Molecular Medicine . 2013 (4)
  • 5Akiko Shibui,Eri Shimura,Aya Nambu,Sachiko Yamaguchi,Warren J. Leonard,Ko Okumura,Sumio Sugano,Katsuko Sudo,Susumu Nakae.Th17 cell-derived IL-17 is dispensable for B cell antibody production[J]. Cytokine . 2012 (1)
  • 6Maria Ciofani,Aviv Madar,Carolina Galan,MacLean Sellars,Kieran Mace,Florencia Pauli,Ashish Agarwal,Wendy Huang,Christopher N. Parkurst,Michael Muratet,Kim M. Newberry,Sarah Meadows,Alex Greenfield,Yi Yang,Preti Jain,Francis K. Kirigin,Carmen Birchmeier,Erwin F. Wagner,Kenneth M. Murphy,Richard M. Myers,Richard Bonneau,Dan R. Littman.A Validated Regulatory Network for Th17 Cell Specification[J]. Cell . 2012 (2)
  • 7Wang-Dong Xu,Yu-Jing Zhang,Wei Wang,Rui Li,Hai-Feng Pan,Dong-Qing Ye.Role of CREM in systemic lupus erythematosus[J]. Cellular Immunology . 2012 (1-2)
  • 8DebjaniGhosh,KatalinKis‐Toth,Yuang‐TaungJuang,George C.Tsokos.CREMα suppresses spleen tyrosine kinase expression in normal but not systemic lupus erythematosus T cells[J]. Arthritis & Rheumatism . 2012 (3)
  • 9Sarah L Gaffen.Recent advances in the IL-17 cytokine family[J]. Current Opinion in Immunology . 2011 (5)
  • 10Sunahori K,Juang YT,Kyttaris VC,et al.Promoter hypomethylation results in increased expression of protein phosphatase 2A in T cells from patients with systemic lupus erythematosus. J Immunol . 2011

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