血小板分布宽度对短期内房颤患者华法林抗凝治疗稳定性达标的预测价值

Value of Platelet Distribution Widthin Predicting Stability Compliance of Warfarin Anticoagulation Therapy in Patients with Atrial Fibrillation in Short Term

目的探讨血小板分布宽度(PDW)对短期内(治疗6个月后)房颤患者使用华法林抗凝治疗稳定性达标[达标时间百分比(TTR)]的预测价值。方法选取174例使用华法林抗凝治疗的持续性房颤患者作为研究对象,按TTR值分为达标组(TTR≥65%)54例与未达标组120例(TTR<65%),比较2组的年龄、性别、合并疾病、合并用药、血液学检查参数,同时采用Pearson相关分析检验PDW水平与TTR之间的相关性。结果2组患者合并冠心病、使用抗血小板药物、PDW异常构成比比较差异有统计学意义(P<0.05);随着PDW的升高,TTR呈下降趋势,二者呈显著负相关(r=-0.843、P<0.001)。结论PDW异常可能影响房颤患者使用华法林抗凝治疗稳定性达标,且随着PDW的升高TTR呈下降趋势。

Objective To explore the value of platelet distribution width(PDW)in predicting stability compliance of warfarin anticoagulation therapy(time in therapeutic range,TTR)in patients with atrial fibrillation in the short term(6 months after treatment).Methods According to the TTR,174 patients with persistent atrial fibrillation who underwent warfarin anticoagulation therapy were divided into two groups:achieved group(54 cases,TTR≥65%)and failed group(120 cases,TTR<65%).The age,gender,complicated diseases,combined medication and hematological parameters were compared between the two groups.The correlation between PDW level and TTR was examined using Pearson correlation analysis.Results There were significant differences between the two groups in the constituent ratios of coronary heart disease,antiplatelet drug use and abnormal PDW(P<0.05).TTR showed a downward trend with the increase of PDW,and there was a negative correlation between the two parameters(r=-0.843,P<0.001).Conclusion Abnormal PDW may affect the stability of warfarin anticoagulation therapy in patients with atrial fibrillation,and TTR tends to decline with the increase of PDW.