吗替麦考酚酯治疗重症肌无力临床疗效探析

Clinical Observation on the Treatment of 18 Cases of Myasthenia Gravis with Mycophenolate Mofetil

为探索吗替麦考酚酯治疗重症肌无力(Myasthenia gravis,MG)的临床疗效。选取2019年1月—2022年12月柳州市工人医院收治的51例MG患者作为研究对象,运用系统随机化法将其分为对照组与实验组。其中,对照组33例患者运用常规治疗方案,给予患者口服泼尼松,实验组18例患者使用吗替麦考酚酯治疗。比较两组患者的治疗总有效率、MG定量评分、不良反应的发生情况以及日常生活状况评分。结果显示,实验组患者的治疗总有效率高于对照组(P<0.05);治疗后,实验组患者的MG定量评分低于对照组,各项指标更接近正常值,恢复情况更优(P<0.05);实验组患者不良反应发生率比对照组低(P<0.05);治疗后,实验组患者的日常生活状况评分显著优于对照组,且治疗时间越长,实验组患者的评分越低,对日常生活的影响越小(P<0.05)。研究发现,吗替麦考酚酯治疗MG患者疗效明显,可降低患者不良反应发生率,提高治疗总有效率,促进患者快速康复,尽早回归正常生活。

Explore the clinical efficacy of mycophenolate mofetil in the treatment of patients with myasthenia gravis(MG).51 MG patients admitted to Liuzhou Workers'Hospital from January 2019 to December 2022 were selected as the research subjects,and were divided into a control group and an experimental group using systematic randomization.Among them,the control group(n=33)received conventional treatment with oral prednisone,while the experimental group(n=18)received treatment with mycophenolate mofetil.Compare the total effective rate of treatment,MG quantitative score before and after treatment,incidence of adverse reactions,and daily living status score before and after treatment between the two groups of patients.The results showed that the total effective rate of treatment in the experimental group was 88.89%,higher than 60.61%in the control group,and the treatment effect in the experimental group was better(P<0.05);Before treatment,there was no significant difference in MG quantitative scores between the two groups of patients(P>0.05).After treatment,the scores of patients in the experimental group were lower than those in the control group,and all indicators were closer to normal values,resulting in better recovery(P<0.05);The number of patients in the experimental group experiencing adverse reactions was lower than that in the control group,and the incidence of adverse reactions was lower than that in the control group(P<0.05);Before treatment,there was no difference in the daily living status scores between the two groups of patients(P>0.05).After treatment,the daily living condition scores of the experimental group patients were significantly better than those of the control group,and the longer the treatment time,the lower the scores of the experimental group patients,and the smaller the impact on daily life(P<0.05).Research has found that the use of mycophenolate mofetil has a significant therapeutic effect on MG patients,reducing the incidence of adverse reactions,improving the overall treatment efficiency,promoting faster recovery,and early return to normal life.It is a relatively high-quality treatment method.