高尔基体蛋白73在非酒精性脂肪性肝病中的应用价值

The Value of Golgi Protein 73 in Nonalcoholic Fatty Liver Disease

目的:探讨高尔基体蛋白73 (GP73)在进行NAFLD诊断标准及排除条件评估后入选的非酒精性脂肪性肝病(NAFLD)中的应用价值。方法:选取2019年1月—8月在福建医科大学附属三明第一医院消化内科住院的430例患者作为研究对象,其中对照组280例(无脂肪肝患者),研究组150例(NAFLD患者),研究组再依据彩超脂肪程度分为中重度组(28例)和轻度组(122例),所有患者均检测血清GP73 (ELISA法)、甘油三酯、胆固醇、空腹血糖水平和计算BMI及统计各组合并2型糖尿病例数,并进行比较分析。结果:研究组患者的BMI、血清GP73、甘油三酯、胆固醇、空腹血糖水平较对照组患者明显升高,且研究组合并2型糖尿病例数较对照组明显增加,差异有统计学意义(P<0.05)。与轻度组比较,中重度组患者血清GP73水平明显升高,差异有统计学意义(t=9.046,P<0.05),但BMI、血清甘油三酯、胆固醇、空腹血糖水平及合并2型糖尿病例数,差异无统计学意义(χ^(2)=0.05,P>0.05)。结论:2型糖尿病、体重超标、高血脂是NAFLD发病的高危因素。NAFLD患者GP73明显高于无脂肪肝正常人群,且与脂肪肝严重程度有关,对NAFLD的诊断及评估病情进展具有临床应用价值。

Objective:To investigate the value of Golgi protein 73(GP73) in non-alcoholic fatty liver disease(NAFLD) and the fact that type 2 diabetes,overweight.Methods:Patients admitted to the hospital from January 2019 to August 2019 were selected for enrollment after assessment of NAFLD diagnostic criteria and exclusion conditions,including 280 patients in the control group(patients without fatty liver) and 150 patients in the study group(patients with NAFLD).The study group was then divided into 28cases in the moderate to severe group and 122 cases in the mild group based on the degree of ultrasound fat.All patients were tested for serum GP73(ELISA method),triglyceride,cholesterol and fasting glucose levels,BMI was calculated,the number of combined type 2 diabetes cases in each group was counted,and comparative analysis was performed.Results:BMI,serum GP73,triglycerides,cholesterol,and fasting glucose levels were significantly higher in the study group compared with the control group,and the number of cases of combined type 2 diabetes was significantly higher in the study group compared with the control group,with statistically significant differences(P<0.05).Compared with the mild group,the serum GP73 level was significantly higher in the moderate-severe group,and the difference was statistically significant(t=9.046,P<0.05).There was no statistically significant difference in BMI,serum triglycerides,cholesterol,fasting glucose levels and number of cases of combined type 2 diabetes when compared(χ^(2)=0.05,P>0.05).Conclusion:Type 2 diabetes,overweight,and hyperlipidemia are high-risk factors for the development of NAFLD.GP73 is significantly higher in patients with NAFLD than in the normal population without fatty liver and is associated with the severity of fatty liver,and has clinical application for the diagnosis of NAFLD and assessment of disease progression.