吡仑帕奈治疗脑梗死后癫痫的效果

Effect of Pirempanel in the Treatment of Epilepsy After Cerebral Infarction

目的 探究吡仑帕奈治疗脑梗死后癫痫的效果。方法 选取2021年3月至2022年10月新乡医学院第二附属医院收治的116例脑梗死后癫痫患者,以随机数字信封法分为对照组和研究组,每组58例。两组均接受基础治疗,对照组接受卡马西平治疗,研究组接受吡仑帕奈治疗。比较两组治疗效果、治疗前后总抗氧化能力(T-AOC)、血清微小核糖核酸-146a(miR-146a)、一氧化氮(NO)、神经元烯醇化酶(NSE)、丙二醛(MDA)、脑电图指标(α波、δ波、θ波)、认知功能(MoCA评分)、日常生活能力(ADL评分)、不良反应。结果 治疗前两组血清MDA、NO、T-AOC、miR-146a、NSE、脑电图指标、MoCA、ADL评分差异无统计学意义(P>0.05)。研究组治疗总有效率高于对照组(P<0.05)。治疗后研究组NO、miR-146a、T-AOC、θ波及δ波高于对照组,ADL、MoCA评分高于对照组,NSE、MDA、α波低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论 吡仑帕奈治疗脑梗死后癫痫效果确切,可减轻患者氧化应激反应,调控miR-146a、NSE表达水平,改善认知功能,提高日常生活能力,且安全性高。

Objective To investigate the effect of pirempanel in the treatment of epilepsy after cerebral infarction.Methods A total of 116 patients with epilepsy after cerebral infarction admitted to the Second Affiliated Hospital of Xinxiang Medical University from March 2021 to October 2022 were randomly divided into control group and study group with 58 cases in each group.Both groups received basic treatment,the control group received carbamazepine treatment,and the research group received pirenpanet treatment.The therapeutic effect,total antioxidant capacity(T-AOC),serum micrornas 146a(miR-146a),nitric oxide(NO),neuronal enolase(NSE),malonaldehyde(MDA),EEG index(αwave,δwave,θwave),cognitive function[Montreal cognitive assessment(MoCA)score],activicy of daily living(ADL)score and adverse reactions were compared between the two groups before and after treatment.Results Before treatment,there was no statistical significance in serum MDA,NO,T-AOC,miR-146a,NSE,EEG,MoCA and ADL scores between the two groups(P>0.05).The total effective rate in the study group was higher than that in the control group(P<0.05).After treatment,the NO,miR-146a,T-AOC,θwave andδwave in the study group were higher than those in the control group,and the scores of ADL and MoCA were higher than those in the control group,while the NSE,MDA andαwave were lower than those in the control group(P<0.05).There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Pirifampanel is effective in treating epilepsy after cerebral infarction,which can reduce the oxidative stress reaction of patients,regulate the expression levels of miR-146a and NSE,improve cognitive function and improve the ability of daily living,and has high safety.