甲状腺功能亢进患者的抑郁情况及其影响因素

The status of depression in patients with hyperthyroidism and its influencing factors

目的 探讨甲状腺功能亢进(甲亢)患者抑郁的影响因素.方法 本研究选择2020年10月~2022年10月100例甲亢患者为研究对象,评估抑郁自评量表(SDS),调查其一般资料以及甲状腺激素水平,经单因素、多因素分析探讨抑郁的影响因素.结果 100例甲亢患者中合并抑郁42例,伴抑郁患者与不伴抑郁患者婚姻状况、文化水平差异具有统计学意义(P<0.05),居住地、性别差异无统计学意义(P>0.05);伴抑郁患者FT_(3)、FT_(4)水平、年龄、病程显著高于不伴抑郁患者,TSH水平显著低于不伴抑郁患者(P<0.05).二元logistic回归线分析显示,未婚、小学及以下文化水平、病程、FT_(3)、FT_(4)、TSH水平是甲亢患者抑郁的影响因素.结论 甲亢患者抑郁率较高,不仅受到甲状腺激素水平的影响,也与婚姻、文化程度、病程等有关.

Objective To explore the factors influencing depression in patients with hyperthyroidism.Methods In this study,100 patients with hyperthyroidism from October 2020 to October 2022 were selected as the study pop-ulation.The depression self-rating scale(SDS)was assessed and their general information as well as thyroid hormone levels were investigated.Factors influencing depression were explored by univariate and multifactorial analysis.Results There were 42 cases of hyperthyroidism combined with depression in 100 patients,and the differences in marital sta-tus and cultural level between depressed and non-depressed patients were statistically significant(P<0.05).The dif-ferences in residence and gender were not statistically significant(P>0.05).Depressed patients had significantly higher FT3 and FT4 levels,age,and duration of illness than non-depressed patients,and significantly lower TSH levels than non-depressed patients(P<0.05).Binary logistic regression line analysis showed that unmarried,elementary school and below literacy level,disease duration,FT3,FT4,and TSH levels were the influencing factors of depression in hyperthyroid patients.Conclusion The higher rate of depression in hyperthyroidism is not only influenced by the level of thyroid hormones,but also related to marriage,literacy,and the duration of the disease.