西酞普兰对慢性阻塞性肺疾病患者负性情绪及生活质量的影响

The effect of citalopram on negative emotions and quality of life in patients with chronic obstructive pulmonary diseas

目的 探讨慢性阻塞性肺疾病(以下简称"慢阻肺")患者应用西酞普兰辅助治疗对其负面情绪及生活质量的改善效果.方法 于2020年1月~2022年12月我院收治的慢阻肺患者共计纳入120例,按照"随机数字表法"分为对照组60例(实行常规药物治疗)与观察组60例(常规药物治疗+西酞普兰);观察对比两组焦虑抑郁程度、睡眠质量和知觉压力水平、治疗依从性、生活质量.结果 干预后,两组焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分均降低,其中观察组更低(P<0.05);干预后,两组匹兹堡睡眠质量指数量表(PSQI)评分、知觉压力量表(CPSS)评分均下降,且观察组显著降低(P<0.05);观察组治疗依从率为95.00%,较对照组的80.00%显著升高(P<0.05);干预后,两组简易健康状况调查表(SF-36)评分均大幅度升高,其中观察组相对更高(P<0.05).结论 在慢阻肺患者治疗中配合应用西酞普兰,可使患者焦虑抑郁程度得到改善,调动其治疗自信心,降低心理压力和强化依从性,全面提高生活质量.

Objective To explore the improvement effect of citalopram adjuvant therapy on negative emotions and quality of life in patients with chronic obstructive pulmonary disease(COPD).Methods From January 2020 to December 2022.A total of 120 patients with chronic obstructive pulmonary disease(COPD)admitted to the hospital were included.Based on the"random number table"method,They were divided into a control group(n=60,pa-tients receiving conventional drug treatment)and The observation group(n=60,patients receiving conventional drug treatment and citalopram).The levels of anxiety and depression,sleep quality,perceived stress levels,treatment compliance,and quality of life were compared between the two groups.Results After the intervention,the SAS and SDS scores of both groups decreased,while the observation group have the lower score(P<0.05).After intervention,the PSQI and CPSS scores of both groups decreased,and the observation group was lower(P<0.05).The treatment compliance rate in the observation group was 95.00%,which was higher than that(80.00%)in the control group(P<0.05).after intervention,the SF-36 scores of both groups significantly increased,the observation group were higher(P<0.05).Conclusion The combination of citalopram in the treatment of patients with chronic obstructive pulmonary disease can significantly improve their anxiety and depression levels,mobilize their treatment confidence,reduce psychological pressure,strengthen compliance,and comprehensively improve their quality of life.