胶原化学改性及应用进展

Chemical Modification and Application Advances of Collagen

胶原是动物组织中含量最高和分布最广的一类蛋白质,按发现顺序分为Ⅰ型胶原、Ⅱ型胶原、Ⅲ型胶原等,其中最常见的为Ⅰ型胶原。胶原具有良好的生物相容性、可降解性、低抗原性以及物理机械性能等,近年来被广泛应用于食品、生物材料、畜牧业、医美等多个领域。文章介绍了不同改性剂对胶原化学改性的特点,包括戊二醛、壳聚糖、京尼平、碳化二亚胺以及聚乙二醇等。同时,归纳了胶原在医疗美容、食品、柔性电子材料等领域的应用研究进展。最后,对胶原未来的推广应用进行了展望。

As one of the most abundant and widely distributed functional proteins in animal tissues and organs,collagen can be classified into types I,II,and III in the order of discovery,with type I collagen being the most common one.Collagen possesses good biocompatibility and degradability as well as low antigenicity,physical and mechanical properties,and has been widely used in recent years in many fields,such as food,biomaterials,animal husbandry,and medical aesthetics.In this paper,the chemical characteristics of modified collagen by different agents were introduced,including glutaraldehyde,chitosan,genipin,carbodiimide,and polyethylene glycol.Meanwhile,the application advances of collagen in the fields of medicine,cosmetics,food,and flexible electronic materials were summarized.Finally,the future promotion and application of collagen was prospected.