复方双氯芬酸钠联合哌替啶、山莨菪碱治疗急性结石性肾绞痛患者的效果

Effects of Compound diclofenac sodium combined with Pethidine and Anisodamine in treatment of patients with acute calculous renal colic

目的:观察复方双氯芬酸钠联合哌替啶、山莨菪碱治疗急性结石性肾绞痛患者的效果。方法:选取2020年10月至2022年10月该院收治的90例急性结石性肾绞痛患者进行前瞻性研究,按随机数字表法将其分为研究组(n=45)与对照组(n=45)。对照组给予哌替啶联合山莨菪碱治疗,研究组在对照组基础上联合复方双氯芬酸钠治疗,比较两组临床疗效、症状持续时间、疼痛程度[视觉模拟评分法(VAS)]评分和不良反应发生率。结果:研究组治疗总有效率为93.33%(42/45),高于对照组的77.78%(35/45),差异有统计学意义(P<0.05);研究组恶心、呕吐、腹痛、发热等症状持续时间均短于对照组,差异有统计学意义(P<0.05);治疗10、30、60 min后,两组VAS评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:复方双氯芬酸钠联合哌替啶、山莨菪碱治疗急性结石性肾绞痛患者可提高治疗总有效率,缩短症状持续时间,降低疼痛程度评分,其效果优于哌替啶联合山莨菪碱治疗。

Objective:To observe effects of Compound diclofenac sodium combined with Pethidine and Anisodamine in treatment of patients with acute calculous renal coli.Methods:A prospective study was conducted on 90 patients with acute calculous renal colic admitted to this hospital from October 2020 to October 2022.They were divided into study group(n=45)and control group(n=45)according to the random number table method.The control group was treated with Pethidine combined with Anisodamine,while the study group was treated with Compound diclofenac sodium on the basis of that of the control group.The clinical efficacy,the symptom duration,the pain degree[visual analogue scale(VAS)]score,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 93.33%(42/45),which was higher than 77.78%(35/45)in the control group,and the difference was statistically significant(P<0.05).The duration of nausea,vomiting,abdominal pain and fever in the study group was shorter than that in the control group,and the difference was statistically significant(P<0.05).After 10,30 and 60 min of treatment,the VAS scores of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Compound diclofenac sodium combined with Pethidine and Anisodamine in the treatment of the patients with acute calculous renal colic can improve the total effective rate of treatment,shorten the duration of symptoms,and reduce the pain scores.Moreover,it is superior to Pethidine combined with Anisodamine treatment.