替硝唑联合阿莫西林治疗急性肠胃炎患者的效果

Effects of Tinidazole combined with Amoxicillin in treatment of patients with acute gastroenteritis

目的:观察替硝唑联合阿莫西林治疗急性肠胃炎患者的效果。方法:选取2020年3月至2021年4月该院收治的60例急性肠胃炎患者进行前瞻性研究,按照随机数字表法将其分为对照组和研究组各30例。对照组采用阿莫西林胶囊治疗,研究组在对照组基础上联合替硝唑片治疗。比较两组临床疗效、临床症状消失时间、治疗前后炎性因子[白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平及不良反应发生率。结果:研究组治疗总有效率为96.67%,高于对照组的73.33%,差异有统计学意义(P<0.05);研究组腹泻消失时间、腹痛消失时间、呕吐消失时间均短于对照组,差异有统计学意义(P<0.05);治疗后,两组IL-6和CRP水平均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:替硝唑联合阿莫西林治疗急性肠胃炎患者,可提高临床疗效,缩短临床症状消失时间,降低炎性因子水平,其效果优于单纯阿莫西林胶囊治疗。

Objective:To observe effects of Tinidazole combined with Amoxicillin in treatment of patients with acute gastroenteritis.Methods:A prospective study was conducted on 60 patients with acute gastroenteritis admitted to the hospital from March 2020 to April 2021.They were divided into control group and study group according to the random number table method,30 cases in each.The control group was treated with Amoxicillin capsules,while the study group was treated with Tinidazole tablets on the basis of that of the control group.The clinical efficacy,the disappearance time of clinical symptoms,the levels of in flammatory factors[interleukin-6(IL-6),C-reactive protein(CR P)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the study group was 96.67%,which was higher than 73.33%in the control group,and the difference was statistically significant(P<0.05).The disappearance time of clinical symptoms such as diarrhea,abdominal pain and vomiting in the study group were shorter than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of IL-6 and CRP in the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Tinidazole combined with Amoxicillin in the treatment of the patients with acute gastroe nteritis can improve the clinical efficacy,shorten the disappearance time of clinical symptoms and reduce the levels of inflammatory factors.Moreover,it is superior to single Amoxicillin capsules treatment.