银杏叶提取物联合多奈哌齐和计算机认知矫正疗法在轻中度阿尔茨海默病患者中的应用效果

Effects of Ginkgo biloba extract combined with Donepezil and computer cognitive correction therapy on patients with mild to moderate Alzheimer’s disease

目的:观察银杏叶提取物联合多奈哌齐和计算机认知矫正疗法在轻中度阿尔茨海默病(AD)患者中的应用效果。方法:选取2020年1月至2022年12月该院收治的102例轻中度AD患者进行前瞻性研究,按照随机数字表法分为研究组与对照组各51例。对照组给予盐酸多奈哌齐片联合计算机认知矫正疗法治疗,研究组在对照组基础上增加银杏叶提取物注射液治疗,比较两组简易智力状态检查量表(MMSE)评分、神经精神科问卷(NPI)评分、Barthel指数(BI)评分、血清炎性因子[白细胞介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)]水平、血清氧化应激指标[丙二醛(MDA)、超氧化物歧化酶(SOD)]水平和不良反应发生率。结果:治疗后,两组MMSE、BI评分和SOD水平高于治疗前,且研究组高于对照组,两组NPI评分、IL-1β水平、TNF-α水平和MDA水平低于治疗前,且研究组低于对照组,差异均有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:银杏叶提取物联合多奈哌齐和计算机认知矫正疗法用于轻中度AD患者可提高其MMSE、BI评分,降低其NPI评分、炎性因子水平,改善氧化应激指标水平,效果优于单纯多奈哌齐和计算机认知矫正疗法治疗。

Objective:To observe effects of Ginkgo biloba extract combined with Donepezil and computer cognitive correction therapy on patients with mild to moderate Alzheimer’s disease(AD).Methods:A prospective study was conducted on 102 patients with mild to moderate AD admitted to this hospital from January 2020 to December 2022.They were divided into study group and control group according to the random number table method,51 cases in each group.The control group was treated with Donepezil hydrochloride tablets combined with computer cognitive correction therapy,while the study group was treated with Ginkgo biloba extract injection on the basis of that of the control group.The mini-mental state examination(MMSE)score,the neuropsychiatric inventory(NPI)score,the Barthel index(BI)score,the serum inflammatory factor levels[interleukin-1β(IL-1β),tumor necrosis factor-α(TNF-α)],the serum oxidative stress index levels[malondialdehyde(MDA),superoxide dismutase(SOD)],and the incidence of adverse reactions were compared between the two groups.Results:After the treatment,the MMSE,the BI scores and the SOD levels in the two groups were higher than those before the treatment,and those in the study group were higher than those in the control group;the NPI score,IL-1βlevel,TNF-αlevel and MDA level of the two groups were lower than those before the treatment,and those in the study group were lower than those in the control group;and the differences were statistically significant(P<0.05).Conclusions:Ginkgo biloba extract combined with Donepezil and computer cognitive correction therapy for the patients with mild to moderate AD can improve their MMSE and BI scores,reduce their NPI scores,inflammatory factor levels,and improve the oxidative stress index levels.Moreover,it is superior to single Donepezil and computer cognitive correction therapy.