全域扫频OCTA与荧光素眼底血管造影在糖尿病视网膜病变应用中的对比分析

Comparison of the application of full range swept-source optical coherence tomography angiography and fundus fluorescein angiography in diabetic retinopathy

目的比较全域扫频光学相干断层扫描血管造影(OCTA)与荧光素眼底血管造影(FFA)对糖尿病视网膜病变(DR)的诊断价值。方法选取2022年2月至2022年4月就诊于安徽医科大学第二附属医院眼科门诊的糖尿病视网膜病变患者35例(70眼),每位患者均使用超广角彩色眼底照相(UWF CFP)检查。采用全域扫频OCTA和FFA分别检查受试者视网膜,并分析两者对视网膜微血管瘤(MA)、视网膜新生血管(RNV)、视网膜无灌注区(NPAs)、视网膜内微血管异常(IRMA)、糖尿病性黄斑水肿(DME)的检出率差异。结果全域扫频OCTA中MA、RNV、NPAs、IRMA、DME的检出率与FFA相比,差异无统计学意义(P>0.05),全域扫频OCTA与FFA对DR的筛查、诊断、分类一致性良好(Kappa值>0.75)。结论全域扫频OCTA在DR应用中具有广阔的前景,可作为DR无创性筛查、诊断、随访的重要依据。

Objective To compare the diagnostic value of full range swept-source optical coherence tomography angiography(OCTA)with fluorescein fundus angiography(FFA)for diabetic retinopathy(DR).Methods A total of 70 eyes of 35 patients with DR who received treatment in the Outpatient Ophthalmology Clinic of the Second Affiliated Hospital of Anhui Medical University from February 2022 to April 2022 were selected.Each patient was examined using ultra-widefield color fundus photography(UWF CFP).The patients'retinas were examined by full range swept-source OCTA and FFA respectively,and the differences in the detection rates of microaneurysm(MA),retinal neovascularization(RNV),nonperfusion areas(NPAs),intraretinal microvascular abnormalities(IRMA),diabetic macular edema(DME)were analyzed.Results The difference in the detection rates of MA,RNV,NPAs,IRMA,and DME in full range swept-source OCTA was not statistically significant compared with FFA(P>0.05),and the screening,diagnosis,and classification of DR by full range swept-source OCTA and FFA were in good agreement(Kappa value>0.75).Conclusions Full range swept-source OCTA has a broad prospect in the application of DR,which can be used as an important basis for non-invasive screening,diagnosis and follow-up of DR.