基于功能磁共振成像技术探讨针刺治疗缺血性脑卒中中枢效应机制

Discussion on the Central Effect Mechanism of Acupuncture for the Treatment of Ischemic Stroke Based on fMRI

针刺治疗缺血性脑卒中的临床疗效已被医学界广泛认可,但其潜在的中枢效应机制尚未明确。功能磁共振成像(fMRI)技术可反映大脑功能、大脑局部血流状态、脑组织代谢情况等,近年来已被广泛应用于神经系统疾病研究。本文从静息态fMRI(局部一致性、低频振幅和分数低频振幅、基于种子点的相关性分析、镜像同位连接及独立成分分析)、弥散张量成像方面梳理针刺治疗缺血性脑卒中fMRI研究现状,进一步探讨其脑可塑性机制,为该病临床诊疗提供神经生物学依据。

The clinical efficacy of acupuncture in treating ischemic stroke has been widely recognized by the medical community,but its potential central effect mechanism has not yet been clarified.Functional magnetic resonance imaging(fMRI)technology can reflect brain functions,local cerebral blood flow status,brain tissue metabolism,etc.In recent years,it has been widely used in the study on nervous system diseases.This article sorted out the current situation of research on acupuncture for the treatment of ischemic stroke based on fMRI from restingstate fMRI(local consistency,low-frequency amplitude and fractional low-frequency amplitude,correlation analysis based on seed points,mirror apposition connection,and independent component analysis)and diffusion tensor imaging,to further explore the mechanism of brain plasticity and provide neurobiological evidence for clinical diagnosis and treatment of this disease.