摘要
抗炎药物具有解热镇痛作用,临床上常用于治疗风湿类疾病以及感冒引起的发热、头痛和牙痛等.近年来抗炎药物在防治结肠癌方面的作用备受关注.本文从炎症在癌症发生过程中的作用、可用于抗肿瘤药物靶点的致炎因子、具有抗炎抗肿瘤双重作用的天然产物的研究进展等几个方面,论述了天然抗炎活性物质用于防治结肠癌的可能性,以期为抗炎药物防治癌症的进一步研究与应用提供参考.
Anti-inflammatory drugs have antipyretic and analgesic effects,and they have been widely used in the treatment of rheumatic diseases and others such as fever,headache and toothache caused by catching cold.In recent years,anti-inflammatory drugs have attracted much attention in the prevention and treatment of colorectal cancer.This mini-review summarizes the role of inflammation in the progression of cancer,discusses the inflammatory factor used as antitumor drug targets,and analyzes natural products with anti-inflammatory and antitumor dual functions.The possibility of anti-inflammatory drugs for the treatment of colon cancer is discussed,expecting further research and application of anti-inflammatory drugs for the prevention and treatment of cancer.
作者
刘凯强
徐嘉焓
侯学友
邓迎开
孙先宇
何卫刚
LIU Kaiqiang;XU Jiahan;HOU Xueyou;DENG Yingkai;SUN Xianyu;HE Weigang(School of Biology and Food Engineering,Changshu Institute of Technology,Changshu 215500,China)
出处
《常熟理工学院学报》
2023年第5期72-77,共6页
Journal of Changshu Institute of Technology
基金
江苏省基础研究计划自然科学基金青年基金项目“基于顺式氢化苯并呋喃骨架构建的malagashanine不对称全合成研究”(BK20210939)
常熟理工学院省级大学生实践创新训练计划项目“含三唑的姜黄素衍生物抗弓形早活性研究”(202210333022Z)。
关键词
结肠癌
慢性炎症
抗炎作用
天然产物
colon cancer
chronic inflammation
anti-inflammatory action
natural products
