壳聚糖负载碘催化合成喹喔啉衍生物

Synthesis of Quinoxaline Derivatives Catalyzed by Chitosan Supported Iodine

喹喔啉及其衍生物是一种重要的化工中间体,被广泛用于生物医药领域,成为药物开发的一个新亮点。以壳聚糖为原料负载单质碘,使用浸渍法制备了壳聚糖负载单质碘(CS/I2)催化剂。通过傅里叶变换红外光谱(FT-IR)、X-射线衍射(XRD)、扫描电子显微镜(SEM)以及X-射线能量色散谱(EDS)对催化剂结构进行表征。以二苯基乙二酮与邻苯二胺缩合反应为模板反应,考察了反应时间、温度、溶剂、原料物质的量比和催化剂用量等因素对产物收率的影响。实验结果表明:碘单质成功负载于壳聚糖载体上,表现出良好的催化活性和较好的稳定性,模板反应产率为99.7%。反应扩大至克级时,产率可达97.3%。反应体系适用性良好,合成的10种喹喔啉衍生物产率为58.4%~99.7%。

Quinoxaline and its derivatives are important chemical intermediates,which are widely used in the field of biomedicine to rise as a new bright spot in drug development.Chitosan supported iodine(CS/I2)catalyst was prepared by impregnation method.The structure of the catalyst was characterized by Fourier transform infrared spectroscopy(FT-IR),X-ray diffraction(XRD),scanning electron microscopy(SEM)and X-ray energy dispersion spectrometry(EDS).The effects of reaction time,temperature,solvent,molar ratio of raw materials and the amount of catalyst on the yield of the product were investigated.The experimental results showed that iodine was successfully loaded on the chitosan carrier and showed good catalytic activity and stability.The yield of template reaction was 99.7%.The yield of 97.3%was also obtained when the reaction was enlarged to gram.The reaction system has good applicability.The yields of 10 quinoxaline derivatives are 58.4%~99.7%.