某院近十年肠球菌属细菌分布及耐药性分析

Analysis of Distribution and Drug Resistance of Enterococcus Bacteria in a Hospital in the Past ten Years

目的探讨本院近十年肠球菌属细菌的临床分布及耐药情况。方法回顾性分析本院2013年至2022年临床分离的肠球菌资料,运用统计学方法分析并总结其构成比及耐药性。结果检出7249株肠球菌,以屎肠球菌4516株(62.30%)和粪肠球菌2457株(33.89%)为主。临床分离标本中,以尿液分离株4935株(占68.08%)最多。屎肠球菌对青霉素G、氨苄西林、环丙沙星、左旋氧氟沙星、红霉素的耐药率在80%以上;对利奈唑胺和奎奴普丁/达福普汀的耐药率低于5%;粪肠球菌对四环素耐药率大于70%;对利奈唑胺、呋喃妥因、氨苄西林的耐药率低于10%。结论利奈唑胺对屎肠球菌和粪肠球菌有较好的抑菌效果,临床需按药敏结果科学用药。

Objective To investigate the clinical distribution and drug resistance of Enterococcus bacteria in our hospital in the past 10 years.Methods The clinical data of enterococci strains isolated in our hospital from2013 to 2022 were retrospectively analyzed,and their constituent ratios and drug resistance were summarized and analyzed using statistical methods.Results A total of 7249 strains of Enterococcus were isolated,when Enterococcus faecium accounted for the highest proportion(4516 strains,62.30%),followed by 2457 strains(33.89%)of Enterococcus faecalis.The most clinically isolated specimen was urine,from which 4935 strains(68.08%)were isolated.The resistance rates of Enterococcus faecium to penicillin G,ampicillin,ciprofloxacin,levofloxacin,and erythromycin were higher than 80%.The drug resistance rates to linezolid and quinuputin/dapfoptin were less than5%;The resistance rate of Enterococcus faecalis to tetracycline was higher than 70%.The resistance rates to linezolid,furantoin,and ampicillin were less than10%.Conclusion linezolid showed good antibacterial effect on Enterococcus faecium and Enterococcus faecalis clinical isolates enrolled in this study,and it is necessary to use the drug scientifically according to the drug sensitivity results in clinical practice.