特布他林雾化吸入辅助盐酸氨溴索对重症肺炎患儿PaO_(2)、PaCO_(2)水平的影响

Effects of Terbutaline Nebulized Inhalation Supplemented with Ambroxol Hydrochloride on PaO_(2) and PaCO_(2) Levels in Children with Severe Pediatric Pneumonia

目的对比分析小儿重症肺炎应用特布他林雾化吸入辅助盐酸氨溴索对患儿PaO_(2)、PaCO_(2)水平的影响。方法遴选本院62例重症肺炎患儿展开回顾性研究,选取时间范围是2015年1月至2023年1月,依据“治疗方式的不同”将其分成对照组与观察组,且每组收入患儿31例,对照组实施特布他林雾化吸入治疗,观察组应用特布他林雾化吸入辅助盐酸氨溴索治疗,系统分析两组的临床效果、血气相关指标(PaO_(2)、PaCO_(2))、炎性因子指标(CRP、PCT及WBC)、药物不良反应率、气促消失时间、咳嗽消失时间、肺部啰音消失时间、体温正常恢复时间以及住院时间。结果治疗后,对比于对照组,观察组FEV_(1)/FVC、FEV_(1)、FVC、PaO_(2)、PaCO_(2)、炎性因子指标CRP、PCT及WBC显著较优(均P<0.05);观察组患儿气促消失时间、咳嗽消失时间、肺部啰音消失时间、体温恢复正常时间以及住院时间短于对照组(P<0.05)。结论重症肺炎患儿应用特布他林雾化吸入辅助盐酸氨溴索治疗可显著提升其临床效果,积极改善肺功能、血气相关指标与炎性因子,缩短气促消失时间、咳嗽消失时间、肺部啰音消失时间、体温恢复正常时间以及住院时间,提高药物安全性。

Objective To compare and analyze the effects of terbutaline nebulized inhalation supplemented with ambroxol hydrochloride on PaO_(2) and PaCO_(2) levels in children with severe pneumonia.Methods Sixty-two children with severe pneumonia in our hospital were selected for a retrospective study from January 2015 to January 2023,and were divided into a control group and an observation group according to"different treatment methods".The clinical effects,blood gas-related indexes(PaO_(2),PaCO_(2)),inflammatory factor indexes(CRP,PCT and WBC),adverse drug reaction rate,time to disappearance of shortness of breath,time to disappearance of cough,time to disappearance of lung rales,time to recovery of normal body temperature,and hospitalization time were systematically analyzed in the two groups.and hospitalization time.Results After treatment,PaO_(2),PaCO_(2),inflammatory factors CRP,PCT and WBC were significantly better in the observation group compared with the control group(all P<0.05);the time to disappearance of shortness of breath,time to disappearance of cough,time to disappearance of lung rales,time to normalization of body temperature and hospitalization time were shorter in the observation group than in the control group(P<0.05).Conclusions The application of terbutaline nebulizer inhalation supplemented with ambroxol hydrochloride in children with severe pneumonia can significantly improve the clinical effect,positively improve pulmonary function,blood gas-related indexes and inflammatory factors,shorten the time to disappearance of shortness of breath,time to disappearance of cough,time to disappearance of lung rales,time to normal recovery of body temperature and time to hospitalization,and improve the safety of the drug.