兰索拉唑、艾司奥美拉唑治疗十二指肠溃疡患者临床对照研究

Clinical ComparativeStudy of Lansoprazole and Esomeprazole in the Treatment of Patients with Duodenal Ulcer

目的研究兰索拉唑、艾司奥美拉唑在十二指肠溃疡患者中的治疗效果。方法选取我院2019年8月至2022年9月收治的120例十二指肠溃疡患者,依据治疗方案不同分为兰索拉唑组和艾司奥美拉唑组各60例。对比两组治疗效果。结果艾司奥拉美唑组疗效显著高于兰索拉唑组(P<0.05);艾司奥拉美唑组症状改善评分显著低于兰索拉唑组(P<0.05);两组出血症状缓解时间、腹痛症状改善时间、溃疡恢复时间比较,差异无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论艾司奥美拉唑治疗十二指肠溃疡,临床治疗效果以及症状改善评分显著优于兰索拉唑。

Objectives To study the therapeutic effect of Lansoprazole and Esomeprazole in patients with duodenal ulcer.Methods A total of 120 patients with duodenal ulcer admitted to our hospital from August 2019 to September 2022 were selected and divided into Lansoprazole group and Esomeprazole group according to differenttreatment regimes,with 60 cases in each group.The therapeutic effects of the two groups were compared.Results After treatment,the efficacyin the Esolamizole group was significantly higher than that of Lansoprazole group(P<0.05).The symptom improvement score of Esolamizole group was significantly lower than that of Lansoprazole group(P<0.05).There was no significant difference between the two groups in the relief time of bleeding symptoms,the improvement time of abdominal pain symptoms and the recovery time of ulcer(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions In the treatment of duodenal ulcer,Esomeprazole is superior to Lansoprazole in clinical treatment effect and symptom improvement score.