维生素D滴剂联合孟鲁司特钠对哮喘患儿血清25-(OH)D水平及肺功能的影响

Effect of Vitamin D Drops combined with Montelukast Sodium on serum 25-(OH)D level and lung function in children with asthma

目的探讨维生素D滴剂联合孟鲁司特钠对哮喘患儿血清25-(OH)D水平及肺功能的影响。方法选择2021年6月至2022年6月景德镇市妇幼保健院收治的68例哮喘患儿为研究对象,按照随机数字表法分为对照组和观察组,每组34例。对照组患者口服孟鲁司特钠,观察组基于此加用维生素D滴剂。比较两组患者的症状改善时间、血清25-(OH)D、肺功能与免疫功能。结果观察组的肺部哮鸣音(2.45±0.58)d、咳嗽(3.19±0.76)d、喘息(2.33±0.54)d、呼吸困难(1.17±0.28)d均短于对照组的(3.83±0.79)d、(4.48±1.56)d、(3.92±0.81)d、(1.93±0.35)d,差异有统计学意义(P<0.05)。两组患者治疗后的血清25-(OH)D水平均高于治疗前,且观察组治疗后的血清25-(OH)D水平高于对照组,差异有统计学意义(P<0.05)。两组治疗后的第1秒用力呼气量(FEV_(1))、用力肺活量(FVC)、最大呼气流量(PEF)水平均高于治疗前,且观察组治疗后的FEV_(1)、FVC、PEF水平均高于对照组,差异有统计学意义(P<0.05)。两组治疗后的CD4、CD4/CD8均高于治疗前,CD8均低于治疗前,且观察组CD4、CD4/CD8均高于对照组,CD8低于对照组,差异有统计学意义(P<0.05)。结论哮喘患儿采用维生素D滴剂联合孟鲁司特钠治疗效果较好,缩短症状改善时间,提升肺功能、血清25-(OH)D水平、免疫功能,值得临床广泛应用。

Objective To investigate the effect of Vitamin D Drops combined with Montelukast Sodium on serum 25-(OH)D level and lung function in children with asthma.Methods Sixty-eight children with asthma admitted to Jingdezhen Maternal and Child Health Hospital from June 2021 to June 2022 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 34 cases in each group.The control group received Montelukast Sodium orally,and the observation group received Vitamin D Drops based on this.Symptom improvement time,serum 25-(OH)D,lung function and immune function were compared between the two groups.Results The pulmonary wheezing(2.45±0.58)d,cough(3.19±0.76)d,wheezing(2.33±0.54)d,dyspnea(1.17±0.28)d in the observation group were shorter than those in the control group(3.83±0.79)d,(4.48±1.56)d,(3.92±0.81)d,(1.93±0.35)d,the differences were statistically significant(P<0.05).The serum 25-(OH)D level after treatment was higher in both groups than before treatment,and the serum 25-(OH)D level after treatment in observation group was higher than that in control group,the differences were statistically significant(P<0.05).The levels of forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC)and peck expiratory flow(PEF)after treatment were higher in both groups than before treatment,and the levels of FEV_(1),FVC and PEF in the observation group were higher than those in the control group after treatment,the differences were statistically significant(P<0.05).CD4 and CD4/CD8 after treatment were higher than before treatment,and CD8 were lower than before treatment,and CD4 and CD4/CD8 in observation group were higher than control group,and CD8 was lower than control group,the differences were statistically significant(P<0.05).Conclusion The treatment effect of Vitamin D Drops combined with Montelukast Sodium in children with asthma is better,shorten the time of symptom improvement,improve lung function,serum 25-(OH)D level and immune function,which is worthy of wide clinical application.