冠心病患者心肌酶谱、Hcy、PCT水平变化及临床意义

Changes and Clinical Significance of Myocardial Enzymes,Hcy and PCT Levels in Patients with Coronary Heart Disease

目的分析冠心病患者心肌酶谱、同型半胱氨酸(Hcy)、降钙素原(PCT)水平变化及临床意义。方法将2021年6月至2022年6月我院收治的60例冠心病患者纳入观察组,并根据SYNTAX评分分为轻度组(19例)、中度组(23例)、重度组(18例)三个亚组;另将同期在我院行健康体检的健康志愿者30例纳入对照组。所有入选者均接受心肌酶谱[谷草转氨酶(AST)、肌酸激酶(CK)、乳酸脱氢酶(LDH)]、Hcy、PCT检测,比较各组AST、CK、LDH、Hcy、PCT水平。结果观察组的AST、CK、LDH、Hcy、PCT水平均高于对照组(P<0.05)。观察组不同病情严重程度患者的AST、CK、LDH、Hcy、PCT水平比较有统计学差异(P<0.05),且随着冠心病严重程度上升,AST、CK、LDH、Hcy、PCT水平显著上升。结论冠心病患者心肌酶谱、Hcy、PCT水平高于正常人,且其病情越严重,心肌酶谱、Hcy、PCT水平越高;联合检测心肌酶谱、Hcy、PCT水平对预测冠心病及其病情严重程度具有重要意义,值得临床应用。

Objective To analyze the changes and clinical significance of myocardial enzymes,homocysteine(Hcy)and procalcitonin(PCT)levels in patients with coronary heart disease.Methods 60 patients with coronary heart disease admitted to our hospital from June 2021 to June 2022 were selected as the observation group,and were divided into mild group(19 cases),moderate group(23 cases)and severe group(18 cases)according to SYNTAX score.In addition,30 healthy volunteers with physical examination in our hospital during the same period were selected and included in the control group.All selected participants received myocardial enzyme spectrum[aspartate aminotransferase(AST),creatine kinase(CK),lactate dehydrogenase(LDH)],Hcy and PCT detection.The AST,CK,LDH,Hcy and PCT levels among groups were compared.Results The AST,CK,LDH,Hcy and PCT levels of the observation group were higher than those of the control group(P<0.05).Statistical difference was found in the AST,CK,LDH,Hcy and PCT levels among patients with different severity in the observation group(P<0.05);with the increase of the severity of coronary heart disease,the AST,CK,LDH,Hcy and PCT levels increased significantly.Conclusions Patients with coronary heart disease had higher myocardial enzyme spectrum,Hcy and PCT levels than normal people.The more serious the disease is,the higher the levels of myocardial enzyme spectrum,Hcy and PCT are;Combined detection of myocardial zymogram,Hcy and PCT levels is of great significance in the prediction of coronary heart disease and its severity,which is worthy of clinical application.