肺炎患者抗生素治疗后伪膜性肠炎发生情况及影响因素分析

Analysis on the Occurence and Influencing Factors of Pseudomembranous Colitis in Pneumonia Patients after Antibiotic Treatment

目的分析肺炎患者抗生素治疗后伪膜性肠炎发生情况及相关影响因素。方法回顾性分析我院应用抗生素治疗的130例肺炎患者的临床资料,根据其治疗后是否发生伪膜性肠炎分为发生组(41例)和未发生组(89例)。统计两组患者的基线资料,采用单因素和Logistic回归分析肺炎患者抗生素治疗后发生伪膜性肠炎的相关影响因素。结果经单因素和多因素Logistic回归分析结果显示,年龄≥60岁、住院时间≥10 d、清洁灌肠、使用泻药、抗生素使用种类≥3种、抗生素使用时间≥10 d是肺炎患者抗生素治疗后发生伪膜性肠炎的危险因素(P<0.05)。结论高龄、住院时间延长、清洁灌肠治疗、使用泻药及抗生素使用不合理均会增加肺炎患者抗生素治疗后伪膜性肠炎发生风险,临床需对上述危险因素重点关注。

Objective To analyze the occurence and related influencing factors of pseudomembranous colitis in pneumonia patients after antibiotic treatment.Methods The clinical data of 130 pneumonia patients with antibiotic treatment in our hospital were retrospectively analyzed.According to whether pseudomembranous colitis occurred after treatment,they were divided into occurrence group(41 cases)and non-occurrence group(89 cases).The baseline data of the two groups were counted.Univariate and Logistic regression analysis were used to analyze the related influencing factors of pseudomembranous colitis in pneumonia patients after antibiotic treatment.Results Univariate and multivariate Logistic regression analysis results showed that age≥60 years,hospitalization time≥10 d,clean enema,use of laxatives,types of antibiotic use≥3,and antibiotic use time≥10 d were risk factors for pseudomembranous colitis in pneumonia patients after antibiotic treatment(P<0.05).Conclusions Advanced age,prolonged hospitalization time,clean enema treatment,unreasonable use of laxatives and antibiotics will increase the risk of pseudomembranous colitis after antibiotic treatment in patients with pneumonia.Clinically,the above risk factors need to be focused on.