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肺癌患者血清肿瘤标志物与凝血功能指标变化的临床研究

Clinical Study on the Changes of Serum Tumor Markers and Coagulation Function Indicators in Patients with Lung Cancer
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摘要 目的分析肺癌患者血清肿瘤标志物与凝血功能指标的相关性,并评估血清肿瘤标志物、凝血功能指标检测对肺癌的诊断价值。方法选取2019年5月至2022年5月我院收治的55例肺癌患者作为观察组,另选同期于我院体检的55例健康者作为对照组。检测并比较两组的肿瘤标志物及凝血功能指标,采用Spearman相关性分析肺癌患者血清肿瘤标志物与凝血功能的相关性;绘制ROC曲线分析血清肿瘤标志物、凝血功能及联合检测对肺癌的临床诊断价值。结果观察组CEA、CA125、CA199水平高于对照组,PT、APTT短于对照组,FIB高于对照组(P<0.05)。CEA、CA125、CA199与PT、APTT呈负相关,与FIB呈正相关(P<0.05)。绘制ROC曲线显示,CEA、CA125、CA199、PT、APTT、FIB、联合检测诊断肺癌的曲线下面积分别为0.745、0.773、0.794、0.787、0.717、0.784、0.933,联合检测诊断效能最高。结论肺癌患者血清肿瘤标志物与凝血功能存在明显相关性,肿瘤标志物水平越高则凝血功能紊乱越严重,血清肿瘤标志物与凝血功能指标联合检测可提高对肺癌的诊断效能。 Objective To analyze the correlation between serum tumor markers and coagulation function indicators in patients with lung cancer,and to evaluate the diagnostic value of serum tumor markers and coagulation function indicators for lung cancer.Methods 55 patients with lung cancer admitted to our hospital from May 2019 to May 2022 were selected as the observation group,and 55 healthy people with physical examination in our hospital during the same period were selected as the control group.The tumor markers and coagulation function indicators of two groups were detected and compared.Spearman correlation was used to analyze the correlation between serum tumor markers and coagulation function in patients with lung cancer.ROC curve was drawn to analyze the clinical diagnostic value of serum tumor markers,coagulation function and combined detection for lung cancer.Results The CEA,CA125 and CA199 levels of the observation group were higher than those of the control group,the PT and APTT were shorter than those of the control group,and the FIB was higher than that of the control group(P<0.05).CEA,CA125 and CA199 were negatively correlated with PT and APTT,and positively correlated with FIB(P<0.05).ROC curve showed that the area under the curve of CEA,CA125,CA199,PT,APTT,FIB and combined detection in the diagnosis of lung cancer was 0.745,0.773,0.794,0.787,0.717,0.784 and 0.933,respectively.The diagnostic efficiency of combined detection was the highest.Conclusions Serum tumor markers are significantly correlated with coagulation function in patients with lung cancer.The higher the level of tumor markers,the more serious the coagulation dysfunction.The combined detection of serum tumor markers and coagulation function indicators can improve the diagnostic efficacy of lung cancer.
作者 郭新蕾 杨涛 李超 GUO Xinlei;YANG Tao;LI Chao(Clinical Laboratory,Jiyuan Tumor Hospital,Jiyuan 456000,China)
出处 《临床医学工程》 2023年第9期1315-1316,共2页 Clinical Medicine & Engineering
关键词 肺癌 肿瘤标志物 凝血功能 相关性 Lung cancer Tumor marker Coagulation function Correlation
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