摘要
综述荷叶生物碱类有效成分抗非酒精性脂肪性肝病(NAFLD)的研究进展。荷叶生物碱类化合物治疗NAFLD疗效显著,其作用机制包括改善脂质代谢和糖代谢、抗氧化应激、减轻炎症反应并抗纤维化及调节肠道菌群等。
This paper reviewed the research progress on alkaloid active ingredients in Heye(Nelumbinis Folium)against non-alcoholic fatty liver disease(NAFLD).Alkaloids in Heye(Nelumbinis Folium)have significant therapeutic effects on NAFLD,and their mechanism of action includes improving lipid and glucose metabolism,antioxidative stress,reducing inflammation,anti-fibrosis,and regulating gut microbiota,etc.
作者
汪晨冉
王乐
杨影
胡宇婷
蔡虹
陆奕宇
WANG Chenran;WANG Le;YANG Ying;HU Yuting;CAI Hong;LU Yiyu(Longhua Clinical Medical College,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Shuguang Clinical Medical College,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Institute of Interdisciplinary Integrative Medicine Research,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Hepatology,Xiamen Hospital of Traditional Chinese Medicine,Xiamen,Fujian 361001,China)
出处
《上海中医药杂志》
CSCD
2023年第10期76-82,共7页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(82274183)
上海市卫健委临床研究专项(202240243)
上海市科委“科技创新行动计划”项目(20ZR1453700)
上海大学生创新活动计划项目(202210268223)
上海中医药大学产业发展中心医养结合科创项目(YYKC-2021-01-117)
厦门市卫健委医学科研计划项目(2021D006)
厦门市中医院医疗卫生科技计划项目(3502Z0214ZD1150)。
关键词
非酒精性脂肪性肝病
荷叶
生物碱
分子机制
中药
研究进展
non-alcoholic fatty liver disease
Heye(Nelumbinis Folium)
alkaloid
molecular mechanism
traditional Chinese herbal medicine
research progress
