抗N-甲基-D-天冬氨酸受体脑炎运动障碍的研究进展

Recent advance in movement disorder of anti-N-methyl-D-aspartate receptor encephalitis

抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎是由NMDAR抗体介导的中枢神经系统自身免疫性疾病。运动障碍是抗NMDAR脑炎的临床特征之一,包括口面部不自主运动、肢体刻板运动等多种形式,对疾病的诊断具有指示作用,但目前临床上对此症状的认识及重视仍不足,且缺乏针对运动障碍的具体治疗策略。本文现围绕抗NMDAR脑炎运动障碍的临床特点及治疗措施等方面的研究进展进行综述,以期提高临床医生对此症状的识别能力及治疗水平。

Anti-N-methyl-D-aspartate receptor(NMDAR)encephalitis is an autoimmune disease of the central nervous system mediated by NMDAR antibodies.Movement disorder is one of the clinical features of anti-NMDAR encephalitis,with various manifestations such as orofacial involuntary movements and limbs stereotypies,which can indicate the disease diagnosis.Currently,the clinical understanding and attention to movement disorder are insufficient,with few treatment strategies.This article reviews the research progress on characteristics and treatment methods of movement disorder of anti-NMDAR encephalitis,aiming to further effectively recognize and treat movement disorder.