合肥市成年男性血清25(OH)D_(3)水平与酒精性脂肪肝病的相关性

Correlation between serum 25(OH)D_(3) levels and alcoholic fatty liver disease in adult males in Hefei

目的探讨合肥市成年男性血清25-羟维生素D_(3)[25⁃hydroxy vitamin D_(3),25(OH)D_(3)]水平与酒精性脂肪肝病(alcohol fatty liver disease,AFLD)的相关性。方法按入选标准收集AFLD患者90例及健康对照90例。通过问卷收集研究对象一般情况,查阅电子病例并收集临床检查资料,采用放射免疫分析法检测血清25(OH)D_(3)水平,logistic回归模型分析血清25(OH)D_(3)水平与AFLD的相关性。结果Mann⁃Whitney U检验显示AFLD患者血清25(OH)D_(3)水平[49.15(39.08,71.09)]低于对照组[67.04(51.03,76.84)](Z=-4.088,P<0.001)。趋势性χ^(2)检验显示AFLD患病率随25(OH)D_(3)水平增加而降低(χ^(2)趋势=13.13,P<0.001)。Mann⁃Whitney U检验显示中重度AFLD组25(OH)D_(3)水平[38.46(30.22,42.41)]低于轻度AFLD组[52.70(42.41,73.13)],且差异有统计学意义(Z=-3.172,P=0.001)。Logistic回归分析模型显示在调整混杂因素后,相对于血清25(OH)D_(3)缺乏的男性,血清25(OH)D_(3)不足和充足男性的AFLD发生风险降低(OR=0.085、OR=0.827)。结论血清25(OH)D_(3)水平与AFLD发生风险及严重程度有关。

Objective To explore the correlation between 25⁃hydroxy vitamin D_(3)[25(OH)D_(3)]level and alcoholic fatty liver disease(AFLD)of adult males in Hefei.Methods A total of 90 patients with AFLD and 90 healthy controls were collected according to the inclusion criteria.General information of study subjects were collected through questionnaires,electronic medical records were consulted and clinical examination data were collected.Serum 25(OH)D_(3) levels were detected by radioimmunoassay.The correlation between serum 25(OH)D_(3) levels and AFLD was analyzed by logistic regression model.Results Mann⁃Whitney U test showed that serum 25(OH)D_(3)[49.15(39.08,71.09)]in patients with AFLD were significantly lower than the control group[67.04(51.03,76.84)](Z=-4.088,P<0.001).Trendingχ^(2)test showed that the prevalence of AFLD increases with increasing 25(OH)D_(3) levels(χ^(2)trend=13.13,P<0.001).Mann⁃Whitney U test showed that the level of 25(OH)D_(3)[38.46(30.22,42.41)]in the moderate to severe AFLD group was significantly lower than that in the mild AFLD group[52.70(42.41,73.13)],and the difference was statistically significant(Z=-3.172,P=0.001).The logistic regression analysis showed that men with insufficient and adequate serum 25(OH)D_(3) had a reduced risk of AFLD when compared with men with serum 25(OH)D_(3) deficiency after adjusting for confounders(OR=0.085,OR=0.827).Conclusion The serum 25(OH)D_(3) level of adult men in Hefei was associated with the risk and severity of AFLD.