黏蛋白型O-糖基化与炎症性肠病的研究进展

Research progress on mucin O-glycosylation and inflammatory bowel disease

炎症性肠病一直被认为是易感个体对肠道微生物群异常免疫激活的结果,具有发病率高、发病人群年轻化、难完全缓解、癌变风险高等特点。目前大量有关炎症性肠病发病机制的研究就是一个探索各因素之间如何相互作用的过程。O-GalNac糖基化又称为黏蛋白型O-糖基化,其高度参与肠道微生物群和肠上皮细胞之间的相互作用,并受宿主遗传学和环境的调节。因此,它们可以很好地整合宿主、微生物和环境之间的关系。本文将就黏蛋白型O-糖基化在炎症性肠病中的生理功能和意义作一综述。

Inflammatory bowel disease(IBD)has been considered to be the result of abnormal immune activation of the intestinal microbiota in susceptible individuals.At present,a large number of studies on the pathogenesis of IBD are a process of exploring how various factors interact.O-GalNac glycosylation,also known as mucin-type O-glycosylation,is highly involved in the interaction between gut microbiota and intestinal epithelial cells.It is regulated by host genetics and environment.Therefore,they can well integrate the relationship between host,microbe and environment.This article reviewed the physiological function and significance of mucin-type O-glycosylation in IBD.