核因子E2相关因子2在肺纤维化中的研究进展

Research progress of nuclear factor erythroid 2-related factor 2 in pulmonary fibrosis

肺纤维化是一种常见的慢性间质性肺病,其特征是细胞外基质过度沉积和肺组织结构重塑,导致肺功能严重受损,其发病原因尚不清楚,因此迫切需要探索其发病机制,寻找对抗肺纤维化的新靶点。研究表明,核因子E2相关因子2可通过调控抗氧化基因,结合抗氧化反应原件来维持机体氧化还原平衡,从而保护组织及细胞免受氧化应激的刺激。近年来,多项研究证明核因子E2相关因子2可通过减轻氧化应激、抑制巨噬细胞极化、激活自噬、抑制铁死亡、阻断上皮细胞-间充质转化等方面发挥抗纤维化作用。本文就核因子E2相关因子2与肺纤维化的联系及研究进展作一简要综述,以期为肺纤维化精准治疗提供新的方向。

Pulmonary fibrosis is a common chronic interstitial lung disease.It is characterized by excessive deposition of extracellular matrix and remodeling of lung tissue structure,resulting in severe impairment of lung function.The cause of its pathogenesis is still unclear.Therefore,it is urgent to explore its pathogenesis and find new targets to combat pulmonary fibrosis.Studies have shown that nuclear factor erythroid 2-related factor 2 can maintain the body's redox homeostasis by regulating antioxidant genes and combining antioxidant response components,thereby protecting tissues and cells from oxidative stress.In recent years,many studies have proved that nuclear factor erythroid 2-related factor 2 can play an anti-fibrotic role by alleviating oxidative stress,inhibiting macrophage polarization,activating autophagy,inhibiting ferroptosis,and blocking epithelial-mesenchymal transition.This paper provides a brief review of the association and research progress of nuclear factor erythroid 2-related factor 2 with pulmonary fibrosis,with the aim of providing a new direction for the precise treatment of pulmonary fibrosis.