正念减压疗法对康复期精神分裂症患者疗效及细胞炎性因子影响的研究

Study on effect of mindfulness-based decompression therapy on convalescent schizophrenic patients and the influence of cellular inflammatory factors

目的研究正念减压疗法(Mindfulness-based stress reduction,MBSR)对康复期精神分裂症患者的疗效及细胞炎性因子的影响,为康复期精神分裂症患者的临床治疗提供新的参考。方法选取2021年6月-2022年6月于精河县人民医院精神卫生中心收治的150例康复期精神分裂症患者为研究对象,使用随机数字表法将其分为对照组和观察组,每组75例。对照组给予常规的药物治疗,观察组在常规治疗的基础上增加正念减压治疗方案,共8周。比较两组患者的临床总体印象量表(CGI)、焦虑自评量表(SAS)、抑郁自评量表(SDS)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、自我效能感量表(GSES)得分以及外周血白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、肿瘤坏死因子(TNF-α)的水平。结果治疗前,观察组和对照组患者的HAMA、HAMD、SAS、SDS、GSES得分及IL-6、IL-1β、TNF-α水平无明显差异。治疗8周后,两组患者的HAMA、HAMD、SAS、SDS得分及IL-6、IL-1β、TNF-α水平明显低于治疗前,GSES得分明显高于治疗前(P<0.05);治疗8周后,观察组患者的HAMA、HAMD、SAS和SDS评分及IL-6、IL-1β、TNF-α水平均明显低于对照组,观察组的自我效能感量表评分(GSES)高于对照组(P<0.05)。观察组的疗效明显优于对照组(P<0.05)。结论正念减压疗法明显提升康复期精神分裂症患者的自我效能且有更好的疗效,并能减轻患者的抑郁和焦虑的严重程度及降低IL-6、IL-1β、TNF-α水平。

Objective To study the effect of mindfulness-based stress reduction(MBSR)on convalescent schizophrenic patients and the effect of cellular inflammatory factors for rehabilitation of the patients with schizophrenia clinical intervention to provide a new reference.Methods A total of 150 convalescent schizophrenia patients admitted to the hospital from June 2021 to June 2022 were selected as the study objects,and the patients were randomly divided into control group and observation group with 75 cases in each group with using random number table method.The control group was given conventional drug treatment,and the observation group was added the mindfulness-based decompression therapy program on the basis of conventional treatment,a total of 8 weeks.The scores of clinical general Impression Scale(CGI),Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS),Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA),Self-efficacy Scale(GSES),and the levels of interleukin-6(IL-6),interleukin-1β(IL-1β)and tumor necrosis factor(TNF-α)were compared between the two groups.Results Before the treatment,there were no significant differences in HAMA,HAMD,SAS,SDS,GSES scores and levels of IL-6,IL-1βand TNF-α.After 8 weeks of the treatment,scores of HAMA,HAMD,SAS and SDS and the levels of IL-6,IL-1βand TNF-αin two groups were significantly lower than before the treatment,while GSES scores were significantly higher than before the treatment(P<0.05).After 8 weeks of the treatment,the HAMA,HAMD,SAS and SDS scores,IL-6,IL-1βand TNF-αlevels in the observation group were significantly lower than those in the control group,and the self-efficacy scale score(GSES)in the observation group was higher than that in the control group(P<0.05),and the efficacy of the observation group was significantly better than that in the control group(P<0.05).Conclusion Mindfulness-based stress reduction therapy can significantly improve the self-efficacy and better efficacy of convalescent schizophrenia patients,reduce the severity of depression and anxiety,and reduce the levels of IL-6,IL-1βand TNF-α.