勃起前后阴茎振动阈和心率测定在早泄发病机制中作用的研究

Study on the role of penile vibration perception threshold and heart rate measurement before and after erection in the pathogenesis of premature ejaculation

目的探究勃起前后阴茎振动阈(VPT)和心率测定在早泄发病机制中的作用。方法选取2020年1月至2021年10月郑州大学第一附属医院男科收治的440例性功能障碍患者作为研究对象。分为早泄组(PE组,n=157)、勃起功能障碍组(ED组,n=168)、早泄合并勃起功能障碍组(PE-ED组,n=115)。另纳入同期选取的35例正常男性作为对照组。比较各组勃起前后的VPT及心率水平。结果勃起前后,ED、PE、PE-ED组的心率均高于对照组,差异具有统计学意义(P<0.05)。勃起前,ED、PE-ED组的心率高于PE组,差异具有统计学意义(P<0.05);勃起后,ED、PE、PE-ED组间心率比较,差异无统计学意义(P>0.05)。ED组勃起后心率低于勃起前,PE组勃起后心率高于勃起前,差异具有统计学意义(P<0.05)。勃起前后,PE组VPT比率均低于ED、PE-ED组,差异具有统计学意义(P<0.05)。勃起后,四组VPT比率均高于勃起前,差异具有统计学意义(P<0.05)。结论早泄患者阴茎敏感度并未升高,交感神经兴奋及对阴茎感觉神经抑制作用减弱可能与早泄的发生相关。

Objective To investigate the role of penile vibration perception threshold(VPT)and heart rate measurement before and after erection in the pathogenesis of premature ejaculation.Methods A total of 440 patients with sexual dysfunction who were admitted to the Department of Andrology of the First Affiliated Hospital of Zhengzhou University from January 2020 to October 2021 were collected as research objects and divided into premature ejaculation group(PE group,n=157),erectile dysfunction group(ED group,n=168),premature ejaculation combined with erectile dysfunction group(PE-ED group,n=115).Another 35 normal males were included in the same period as the control group.The VPT and heart rate levels before and after erection were compared in each group.Results The heart rate of ED,PE,PE-ED groups were higher than that of control group before and after erection(P0.05).The heart rate of ED and PE-ED groups before erection was higher than that of PE group(P0.05);and after erection,there was no statistically significant difference in heart rate among ED,PE and PE-ED groups(P0.05).The heart rate after erection in ED group was lower than that before erection,and the heart rate after erection in PE group was higher than that before erection,and the difference was statistically significant(P0.05).No matter before or after erection,the VPT ratio of PE group was lower than that of ED group and PE-ED group,and the difference was statistically significant(P0.05).The VPT ratios of the four groups after erection were higher than those before erection,and the difference was statistically significant(P0.05).Conclusions The sensitivity of penis in patients with premature ejaculation did not increase,and the excitation of sympathetic nerves and the weakening of the inhibitory effect on penile sensory nerves may be related to the occurrence of premature ejaculation.