子痫前期患者血清脑啡肽酶水平表达与围产结局的相关性研究

Correlation between the expression of serum neprilysin and perinatal outcome in patients with preeclampsia

目的探究子痫前期患者血清脑啡肽酶(NEP)水平与围产结局的相关性。方法选取2018年1月至2022年3月监利市人民医院收治的94例子痫前期患者作为观察组,根据患者病情严重程度,分为轻度组(n=52)和重度组(n=42);选取同时期同一医院98例健康的单胎妊娠孕妇作为对照组。采用酶联免疫吸附试验(ELISA)法测定血清NEP水平;测量胎儿搏动指数(PI)、阻力指数(RI)、脐动脉收缩压与舒张压的比值(S/D)。随访至所有子痫前期患者围产期结束,分为围产期结局不良组(n=18)和围产期结局良好组(n=76)。采用Pearson法对子痫前期患者血清NEP与S/D、PI、RI的相关性进行分析;Logistic回归分析影响子痫前期患者围产期不良结局的危险因素。结果观察组血清NEP水平显著高于对照组(P<0.05),重度组血清NEP水平显著高于轻度组(P<0.05),围产期结局不良组血清NEP水平及S/D、PI、RI显著高于围产期结局良好组(P<0.05)。子痫前期患者血清中NEP与S/D、PI、RI呈正相关(P<0.05)。Logistic回归分析显示,S/D、PI、RI、NEP是子痫前期患者围产期不良结局的危险因素(P<0.05)。结论子痫前期患者血清NEP水平显著升高,且其是围产期不良结局的危险因素。

Objective To investigate the correlation between serum neprilysin(NEP)level and perinatal outcomes in patients with preeclampsia.Methods From January 2018 to March 2022,94 patients with preeclampsia who were treated in Jianli People′s Hospital were selected as the observation group.According to the severity of the patients,they were grouped into a mild group(n=52)and a severe group(n=42);another 98 healthy pregnant women with singleton pregnancy in the same hospital during the same period were selected as the control group.An enzyme-linked immunosorbent assay(ELISA)was used to measure serum NEP level.Fetal pulsatility index(PI),resistance index(RI),and umbilical artery systolic to diastolic(S/D)values were measured.All patients with preeclampsia were followed up until the end of the perinatal period,and they were grouped into a poor perinatal outcome group(n=18)and a good perinatal outcome group(n=76).Pearson′s method was applied to analyze the correlation of serum NEP with S/D,PI and RI in patients with preeclampsia.Logistic regression was applied to analyze risk factors for adverse perinatal outcomes in patients with preeclampsia.Results The serum NEP level in the observation group was obviously higher than that in the control group(P0.05),the serum NEP level in the severe group was obviously higher than that in the mild group(P0.05),the serum NEP level,S/D,PI and RI in the poor perinatal outcome group were obviously higher than those in the good perinatal outcome group(P0.05).Serum NEP was positively correlated with S/D,PI and RI in patients with preeclampsia(P0.05).Logistic analysis showed that S/D,PI,RI,and NEP were risk factors for adverse perinatal outcomes in patients with preeclampsia(P0.05).Conclusions Serum NEP level in patients with preeclampsia is obviously increased,which is a risk factor for adverse perinatal outcomes in patients with preeclampsia.