培哚普利联合氢氯噻嗪对老年高血压患者血压变异性及炎症因子表达的影响

Effects of Perindopril Combined with Hydrochlorothiazide on Blood Pressure Variability and Expression of Inflammatory Factors in Elderly Patients with Hypertension

目的培哚普利+氢氯噻嗪治疗后,对老年高血压患者的血压变异性进行评价,分析其对炎症因子的作用水平。方法选取郑州市第二人民医院2020年3月至2021年3月收治的64例老年高血压患者为探究对象,按数字表法,将患者分为联合组及单一组,各32例。两组患者均行基础治疗,单一组行氢氯噻嗪治疗,联合组行培哚普利+氢氯噻嗪治疗。评价两组患者的血压变异性,比较C反应蛋白(CRP)、肿瘤坏死因子α(TNF-α)及白介素6(IL-6)、内皮素、一氧化氮水平。比较两组患者的不良反应发生情况及生活或质量。结果治疗前,两组血压变异性比较,差异无统计学意义(P>0.05);治疗后,两组患者收缩压变异性、舒张压变异性、CRP、TNF-α、IL-6水平较治疗前呈现显著降低趋势,且联合组患者的上述指标均低于单一组,差异有统计学意义(P<0.05)。治疗前,两组患者内皮素、一氧化氮水平比较,差异无统计学意义(P>0.05);治疗后,联合组患者的内皮素低于单一组,一氧化氮水平高于单一组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P=0.862)。联合组生活质量评分高于单一组,差异有统计学意义(P<0.05)。结论培哚普利+氢氯噻嗪治疗高血压协同效果良好,可控制患者血压,减少炎症反应,改善内皮素与一氧化氮水平,且不增加不良反应,临床安全可靠。

Objective To evaluate the variability of blood pressure in elderly patients with hypertension after perindopril+hydrochlorothiazide treatment,and to analyze its effect on inflammatory factors.Methods A total of 64 elderly patients with hypertension admitted to the Second People's Hospital of Zhengzhou from March 2020 to March 2021 were selected as the research objects.According to the number table method,the patients were divided into the combined group and the single group,with 32 cases in each group.Two groups of patients were treated with basic treatment,the single group was treated with hydrochlorothiazide,and the combination group was treated with perindopril+hydrochlorothiazide.The blood pressure variability of the two groups was evaluated,and the levels of C-reactive protein(CRP),tumor necrosis factorα(TNF-α),interleukin-668 Clinical Research,Oct.2023,Vol.31 No.10(IL-6),endothelin and nitric oxide were compared.The incidence of adverse reactions and quality of life were compared between the two groups.Results Before treatment,there was no significant difference in blood pressure variability between the two groups(P>0.05).After treatment,the levels of systolic blood pressure variability,diastolic blood pressure variability,CRP,TNF-αand IL-6 in the two groups showed significantly lower trends than those before treatment,and the above indicators in the combined group were lower than those in the single group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of endothelin and nitric oxide between the two groups(P>0.05).After treatment,the endothelin and nitric oxide levels in the combination group were lower than those in the single group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P=0.862).The life quality score of the combined group was higher than that of the single group,and the difference was statistically significant(P<0.05).Conclusion Perindopril+hydrochlorothiazide has a good synergistic effect in the treatment of hypertension,which can control blood pressure,reduce inflammation,improve endothelin and nitric oxide levels without increasing adverse reactions,and is safe and reliable in the clinic.