小檗碱抗幽门螺杆菌的药理作用及其临床使用研究进展

Research Progress in Pharmacological Effects and Clinical Use of Berberine against Helicobacter Pylori

小檗碱具有广泛的抗微生物作用,除了球菌、病毒、真菌外,对体内、体外的幽门螺杆菌(Helicobacter pylori,Hp)也有较强的抑杀作用。并且,小檗碱主要抑杀稳定期的Hp,若与主要抑杀对数生长期的抗Hp药物联用,则可产生协同杀菌的作用。该文就小檗碱对体内与体外、动物与人的Hp的抗菌作用,以及与其他抗Hp药物联用的临床实践进行了综述,为小檗碱下一步的临床开发提供参考。

Berberine has a wide range of antimicrobial effects.It has a strong inhibitory effect on Helicobacter pylori(Hp)in vivo and in vitro in addition to cocci,viruses and fungi.Moreover,berberine mainly inhibits and kills Hp in the stable phase.When berberine is used in combination with anti-Hp drugs that mainly inhibit and kill Hp in the logarithmic growth phase,a synergistic bactericidal effect can be produced.This article summarizes the antibacterial effects of berberine on Hp in vivo and in vitro,in animals and humans,and the clinical practice of combination with other anti-Hp drugs,providing reference for the subsequent clinical development of berberine.