特发性快速眼动睡眠期行为障碍向神经系统变性疾病转化的生物学标志物研究进展

Progress on biomarkers of idiopathic rapid eye movement sleep behavior disorder conversion to neurodegenerative diseases

特发性快速眼动睡眠期行为障碍(iRBD)是神经系统变性疾病的前驱症状,多数患者可转化为神经系统变性疾病,可靠的生物学标志物对早期识别高风险转化者和预测疾病转化表型具有重要意义。本文从临床症状学、神经电生理学、神经影像学、体液、病理学、基因标志物等方面综述iRBD转化为神经系统变性疾病的生物学标志物研究进展,以优选适宜疾病修饰治疗的患者,并延缓神经系统变性疾病进展。

Idiopathic rapid eye movement sleep behavior disorde(iRBD)is a precursor symptom of neurodegenerative diseases,and most patients will convert to neurodegenerative diseases later in the disease.Reliable biological markers are of great significance for early identification of high-risk converters and predicting phenoconversion pattern.This paper reviews the research progress of biological markers in predicting conversion to neurodegenerative diseases in iRBD from clinical symptomology,neuroelectrophysiology,neuroimaging,body fluid,pathology and gene markers,in order to select patients suitable for disease modification therapy and delay the development of neurodegenerative diseases.