发作性睡病与焦虑研究进展

Progress on narcolepsy and anxiety

发作性睡病是以日间过度思睡、猝倒发作、入睡前幻觉、睡眠瘫痪为主要临床表现的罕见睡眠障碍,绝大多数患者伴焦虑。发作性睡病与焦虑的神经回路之间存在神经元的相互连接与投射,二者可能存在共同的病理生理学机制,且部分用于治疗发作性睡病猝倒发作的药物可改善焦虑。本研究对发作性睡病伴焦虑的流行病学、发病机制和治疗进行综述,以提高临床对发作性睡病伴焦虑的诊断与治疗水平,改善患者预后。

Narcolepsy is a rare sleep disorder characterized by excessive daytime sleepiness(EDS),cataplexy,sleep hallucination and sleep paralysis,and the vast majority of patients are accompanied by anxiety.There are neuronal interconnections and projections between the neural circuits of narcolepsy and anxiety,which may share common pathophysiology mechanisms,and some medications used clinically to treat cataplexy in narcolepsy may also improve anxiety.In this study,we propose to review the epidemiologic research,pathogenesis and therapeutic advances in narcolepsy with anxiety,with the aim of increasing the diagnosis and treatment of narcolepsy with anxiety and improving the prognosis of narcolepsy with anxiety patients.